Intravenous sub-anesthetic ketamine for perioperative analgesia
Ketamine, an N-methyl-d-aspartate antagonist, blunts central pain sensitization at sub-anesthetic doses (0.3 mg/kg or less) and has been studied extensively as an adjunct for perioperative analgesia. At sub-anesthetic doses, ketamine has a minimal physiologic impact though it is associated with a lo...
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Wolters Kluwer Medknow Publications
2016-01-01
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doaj-56fb18cb8cf94918857ae57fd42ba11d2020-11-25T00:07:11ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852016-01-0132216016710.4103/0970-9185.182085Intravenous sub-anesthetic ketamine for perioperative analgesiaAndrew W GorlinDavid M RosenfeldHarish RamakrishnaKetamine, an N-methyl-d-aspartate antagonist, blunts central pain sensitization at sub-anesthetic doses (0.3 mg/kg or less) and has been studied extensively as an adjunct for perioperative analgesia. At sub-anesthetic doses, ketamine has a minimal physiologic impact though it is associated with a low incidence of mild psychomimetic symptoms as well as nystagmus and double vision. Contraindications to its use do exist and due to ketamine′s metabolism, caution should be exercised in patients with renal or hepatic dysfunction. Sub-anesthetic ketamine improves pain scores and reduces perioperative opioid consumption in a broad range of surgical procedures. In addition, there is evidence that ketamine may be useful in patients with opioid tolerance and for preventing chronic postsurgical pain.http://www.joacp.org/article.asp?issn=0970-9185;year=2016;volume=32;issue=2;spage=160;epage=167;aulast=GorlinKetamine, N-methyl-d-aspartate, pain |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrew W Gorlin David M Rosenfeld Harish Ramakrishna |
spellingShingle |
Andrew W Gorlin David M Rosenfeld Harish Ramakrishna Intravenous sub-anesthetic ketamine for perioperative analgesia Journal of Anaesthesiology Clinical Pharmacology Ketamine, N-methyl-d-aspartate, pain |
author_facet |
Andrew W Gorlin David M Rosenfeld Harish Ramakrishna |
author_sort |
Andrew W Gorlin |
title |
Intravenous sub-anesthetic ketamine for perioperative analgesia |
title_short |
Intravenous sub-anesthetic ketamine for perioperative analgesia |
title_full |
Intravenous sub-anesthetic ketamine for perioperative analgesia |
title_fullStr |
Intravenous sub-anesthetic ketamine for perioperative analgesia |
title_full_unstemmed |
Intravenous sub-anesthetic ketamine for perioperative analgesia |
title_sort |
intravenous sub-anesthetic ketamine for perioperative analgesia |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Anaesthesiology Clinical Pharmacology |
issn |
0970-9185 |
publishDate |
2016-01-01 |
description |
Ketamine, an N-methyl-d-aspartate antagonist, blunts central pain sensitization at sub-anesthetic doses (0.3 mg/kg or less) and has been studied extensively as an adjunct for perioperative analgesia. At sub-anesthetic doses, ketamine has a minimal physiologic impact though it is associated with a low incidence of mild psychomimetic symptoms as well as nystagmus and double vision. Contraindications to its use do exist and due to ketamine′s metabolism, caution should be exercised in patients with renal or hepatic dysfunction. Sub-anesthetic ketamine improves pain scores and reduces perioperative opioid consumption in a broad range of surgical procedures. In addition, there is evidence that ketamine may be useful in patients with opioid tolerance and for preventing chronic postsurgical pain. |
topic |
Ketamine, N-methyl-d-aspartate, pain |
url |
http://www.joacp.org/article.asp?issn=0970-9185;year=2016;volume=32;issue=2;spage=160;epage=167;aulast=Gorlin |
work_keys_str_mv |
AT andrewwgorlin intravenoussubanestheticketamineforperioperativeanalgesia AT davidmrosenfeld intravenoussubanestheticketamineforperioperativeanalgesia AT harishramakrishna intravenoussubanestheticketamineforperioperativeanalgesia |
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