Salivary exosomal microRNAs as biomarkers for head and neck cancer detection—a literature review
Abstract Background MicroRNAs (miRs) are small, non-coding mRNA molecules which regulate cellular processes in tumorigenesis. miRs were discovered in extracellular environment and biological fluids, carrying marks of head and neck squamous cell carcinoma (HNSCC). They were also identified in abundan...
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doaj-57040670b4714511a9af8690496a745b2021-07-04T11:19:14ZengSpringerOpenMaxillofacial Plastic and Reconstructive Surgery2288-85862021-06-0143111110.1186/s40902-021-00303-9Salivary exosomal microRNAs as biomarkers for head and neck cancer detection—a literature reviewCosmin Ioan Faur0Horatiu Rotaru1Ciprian Osan2Ancuta Jurj3Rares Calin Roman4Madalina Moldovan5Magdalena Chirila6Mihaela Hedesiu7Department of Oral Radiology, “Iuliu Hatieganu” University of Medicine and PharmacyDepartment of Oral and Cranio-Maxillofacial Surgery, “Iuliu Hatieganu” University of Medicine and PharmacyFaculty of Dental Medicine, “Iuliu Hatieganu” University of Medicine and PharmacyResearch Center for Functional Genomics, Biomedicine and Translational Medicine, “Iuliu Hatieganu” University of Medicine and PharmacyDepartment of Oral and Cranio-Maxillofacial Surgery, “Iuliu Hatieganu” University of Medicine and PharmacyDepartment of Oral and Cranio-Maxillofacial Surgery, “Iuliu Hatieganu” University of Medicine and PharmacyDepartment of Otorhinolaryngology, “Iuliu Hatieganu” University of Medicine and PharmacyDepartment of Oral Radiology, “Iuliu Hatieganu” University of Medicine and PharmacyAbstract Background MicroRNAs (miRs) are small, non-coding mRNA molecules which regulate cellular processes in tumorigenesis. miRs were discovered in extracellular environment and biological fluids, carrying marks of head and neck squamous cell carcinoma (HNSCC). They were also identified in abundance in salivary exosomes, in which they are protected by exosome lipid barrier against enzymatic injuries and therefore, the accuracy of exosomal miR-based cancer detection increase. This systematic review aimed to reveal and inventorize the most reliable exosomal miRNAs in saliva samples which can be used as novel biomarkers for early detection of HNSCC. Materials and methods A systematic literature search, according to PRISMA guideline, was performed on Pubmed and Google Academic libraries, based on specific keywords. Original articles published between 2010 and 2021 were selected. The quality of each paper was assessed using the Quality Evaluation Scoring Tool. Results At the end of selection process, five studies met the inclusion criteria. These studies analyzed twelve salivary exosomal miRs, presenting different methods of exosome and miR identification for HNSCC detection. A comprehensive explanation of the miR pathways of action was drawn and illustrated in this review. Conclusion Exosomal miRs are promising biomarkers for oral cavity and oropharyngeal cancer detection. miR-10b-5p, miR-486-5p, miR-24-3p and miR-200a stand as the most useful ones in saliva sample examination.https://doi.org/10.1186/s40902-021-00303-9HNSCCExosomeExtracellular microRNABiomarkerSaliva |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cosmin Ioan Faur Horatiu Rotaru Ciprian Osan Ancuta Jurj Rares Calin Roman Madalina Moldovan Magdalena Chirila Mihaela Hedesiu |
spellingShingle |
Cosmin Ioan Faur Horatiu Rotaru Ciprian Osan Ancuta Jurj Rares Calin Roman Madalina Moldovan Magdalena Chirila Mihaela Hedesiu Salivary exosomal microRNAs as biomarkers for head and neck cancer detection—a literature review Maxillofacial Plastic and Reconstructive Surgery HNSCC Exosome Extracellular microRNA Biomarker Saliva |
author_facet |
Cosmin Ioan Faur Horatiu Rotaru Ciprian Osan Ancuta Jurj Rares Calin Roman Madalina Moldovan Magdalena Chirila Mihaela Hedesiu |
author_sort |
Cosmin Ioan Faur |
title |
Salivary exosomal microRNAs as biomarkers for head and neck cancer detection—a literature review |
title_short |
Salivary exosomal microRNAs as biomarkers for head and neck cancer detection—a literature review |
title_full |
Salivary exosomal microRNAs as biomarkers for head and neck cancer detection—a literature review |
title_fullStr |
Salivary exosomal microRNAs as biomarkers for head and neck cancer detection—a literature review |
title_full_unstemmed |
Salivary exosomal microRNAs as biomarkers for head and neck cancer detection—a literature review |
title_sort |
salivary exosomal micrornas as biomarkers for head and neck cancer detection—a literature review |
publisher |
SpringerOpen |
series |
Maxillofacial Plastic and Reconstructive Surgery |
issn |
2288-8586 |
publishDate |
2021-06-01 |
description |
Abstract Background MicroRNAs (miRs) are small, non-coding mRNA molecules which regulate cellular processes in tumorigenesis. miRs were discovered in extracellular environment and biological fluids, carrying marks of head and neck squamous cell carcinoma (HNSCC). They were also identified in abundance in salivary exosomes, in which they are protected by exosome lipid barrier against enzymatic injuries and therefore, the accuracy of exosomal miR-based cancer detection increase. This systematic review aimed to reveal and inventorize the most reliable exosomal miRNAs in saliva samples which can be used as novel biomarkers for early detection of HNSCC. Materials and methods A systematic literature search, according to PRISMA guideline, was performed on Pubmed and Google Academic libraries, based on specific keywords. Original articles published between 2010 and 2021 were selected. The quality of each paper was assessed using the Quality Evaluation Scoring Tool. Results At the end of selection process, five studies met the inclusion criteria. These studies analyzed twelve salivary exosomal miRs, presenting different methods of exosome and miR identification for HNSCC detection. A comprehensive explanation of the miR pathways of action was drawn and illustrated in this review. Conclusion Exosomal miRs are promising biomarkers for oral cavity and oropharyngeal cancer detection. miR-10b-5p, miR-486-5p, miR-24-3p and miR-200a stand as the most useful ones in saliva sample examination. |
topic |
HNSCC Exosome Extracellular microRNA Biomarker Saliva |
url |
https://doi.org/10.1186/s40902-021-00303-9 |
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