Recent Applications of Supercritical Fluid Technology to Pharmaceutical Powder Systems

Recent Applications of Supercritical Fluid Technology to Pharmaceutical Powder Systems

The unique characteristics of supercritical fluids can be utilised to overcome the drawbacks associated with the conventional techniques for the generation of pharmaceutical powders. These characteristics include high diffusivity compared with...

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Main Authors: Rana T. Bustami, Hak-Kim Chan, Fariba Dehghani, Neil R. Foster
Format: Article
Language:English
Published: Hosokawa Powder Technology Foundation 2014-05-01
Series:KONA Powder and Particle Journal
Online Access:https://www.jstage.jst.go.jp/article/kona/19/0/19_2001011/_pdf/-char/en
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spelling doaj-57047084371a49dfb91de83e46c508342021-02-03T01:13:23ZengHosokawa Powder Technology FoundationKONA Powder and Particle Journal0288-45342187-55372014-05-01190577010.14356/kona.2001011konaRecent Applications of Supercritical Fluid Technology to Pharmaceutical Powder SystemsRana T. Bustami0Hak-Kim Chan1Fariba Dehghani2Neil R. Foster3Faculty of Pharmacy, The University of SydneyFaculty of Pharmacy, The University of SydneySchool of Chemical Engineering and Industrial Chemistry, University of New South WalesSchool of Chemical Engineering and Industrial Chemistry, University of New South WalesThe unique characteristics of supercritical fluids can be utilised to overcome the drawbacks associated with the conventional techniques for the generation of pharmaceutical powders. These characteristics include high diffusivity compared with those of liquids, relatively high solvent density and solvent power intermediate between those of gases and liquids. Such characteristics make it possible to use supercritical fluids either as solvents or antisolvents. The application of supercritical fluid technology to various pharmaceutical processes such as micronisation of a wide spectrum of pharmaceutical compounds, encapsulation and polymer impregnation, coprecipitation of pharmaceutical compounds and liposome formation, has been explored. The present review critically discusses the novel supercritical fluid techniques that are currently available and the applications of such techniques to pharmaceutical powder systems.https://www.jstage.jst.go.jp/article/kona/19/0/19_2001011/_pdf/-char/en
collection DOAJ
language English
format Article
sources DOAJ
author Rana T. Bustami
Hak-Kim Chan
Fariba Dehghani
Neil R. Foster
spellingShingle Rana T. Bustami
Hak-Kim Chan
Fariba Dehghani
Neil R. Foster
Recent Applications of Supercritical Fluid Technology to Pharmaceutical Powder Systems
KONA Powder and Particle Journal
author_facet Rana T. Bustami
Hak-Kim Chan
Fariba Dehghani
Neil R. Foster
author_sort Rana T. Bustami
title Recent Applications of Supercritical Fluid Technology to Pharmaceutical Powder Systems
title_short Recent Applications of Supercritical Fluid Technology to Pharmaceutical Powder Systems
title_full Recent Applications of Supercritical Fluid Technology to Pharmaceutical Powder Systems
title_fullStr Recent Applications of Supercritical Fluid Technology to Pharmaceutical Powder Systems
title_full_unstemmed Recent Applications of Supercritical Fluid Technology to Pharmaceutical Powder Systems
title_sort recent applications of supercritical fluid technology to pharmaceutical powder systems
publisher Hosokawa Powder Technology Foundation
series KONA Powder and Particle Journal
issn 0288-4534
2187-5537
publishDate 2014-05-01
description The unique characteristics of supercritical fluids can be utilised to overcome the drawbacks associated with the conventional techniques for the generation of pharmaceutical powders. These characteristics include high diffusivity compared with those of liquids, relatively high solvent density and solvent power intermediate between those of gases and liquids. Such characteristics make it possible to use supercritical fluids either as solvents or antisolvents. The application of supercritical fluid technology to various pharmaceutical processes such as micronisation of a wide spectrum of pharmaceutical compounds, encapsulation and polymer impregnation, coprecipitation of pharmaceutical compounds and liposome formation, has been explored. The present review critically discusses the novel supercritical fluid techniques that are currently available and the applications of such techniques to pharmaceutical powder systems.
url https://www.jstage.jst.go.jp/article/kona/19/0/19_2001011/_pdf/-char/en
work_keys_str_mv AT ranatbustami recentapplicationsofsupercriticalfluidtechnologytopharmaceuticalpowdersystems
AT hakkimchan recentapplicationsofsupercriticalfluidtechnologytopharmaceuticalpowdersystems
AT faribadehghani recentapplicationsofsupercriticalfluidtechnologytopharmaceuticalpowdersystems
AT neilrfoster recentapplicationsofsupercriticalfluidtechnologytopharmaceuticalpowdersystems
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