Complete Remission of Acute Myeloid Leukemia in Induction and Consolidation Chemotherapy without Bone Marrow Transplantation: Lessons Learned from Good Presentation Case
Acute myeloid leukemia (AML) is a clinically morphologically and genetically heterogeneous disease with variable responses to therapy. The majority of the patients eventually relapse and succumb to the disease. Therapeutic modalities of induction chemotherapy, consolidation, and bone marrow transpla...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Universitas Padjajaran
2019-03-01
|
Series: | Majalah Kedokteran Bandung |
Subjects: | |
Online Access: | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/1634 |
id |
doaj-570604d053a84dd69efa772e5e8fa33d |
---|---|
record_format |
Article |
spelling |
doaj-570604d053a84dd69efa772e5e8fa33d2020-11-25T02:34:28ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232019-03-01511313810.15395/mkb.v51n1.16341056Complete Remission of Acute Myeloid Leukemia in Induction and Consolidation Chemotherapy without Bone Marrow Transplantation: Lessons Learned from Good Presentation CaseTuti Sri Hastuti0Rachmat Sumantri1Indra Wijaya2Department of Internal Medicine, General Hospital of CianjurDivision of Medical Hematology-Oncology, Department of Internal Medicine Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDivision of Medical Hematology-Oncology, Department of Internal Medicine Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungAcute myeloid leukemia (AML) is a clinically morphologically and genetically heterogeneous disease with variable responses to therapy. The majority of the patients eventually relapse and succumb to the disease. Therapeutic modalities of induction chemotherapy, consolidation, and bone marrow transplantation are intended to achieve complete remission. Induction therapy with cytarabine and anthracycline remains thestandard of care in AML. Consolidation treatment is necessary to prevent recurrence, which may reach 90% without this treatment. Options for consolidation therapy are conventional chemotherapy and bone marrow transplantation. Bone marrow transplantation represents the only realistic chance of long-term remission in patients with a high cytogenetic risk. The risk of recurrence of AML is determined mainly by the patient’s age and genetic factors. In younger patients, complete remission (CR) rates of ≥80% may be achieved, with 5-year overall survival (OS) of 40%. InDr. Hasan Sadikin Hospital Bandung during the period of 2013-2018, 12 cases of LMA underwent chemotherapy. This case study discusses a young patient with AML who has successfully reached complete remission using induction and consolidation chemotherapy without bone marrow transplantation. Key words: Acute myeloid leukemia, chemotherapy, complete remissionhttp://journal.fk.unpad.ac.id/index.php/mkb/article/view/1634Acute myeloid leukemia, chemotherapy, complete remission |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tuti Sri Hastuti Rachmat Sumantri Indra Wijaya |
spellingShingle |
Tuti Sri Hastuti Rachmat Sumantri Indra Wijaya Complete Remission of Acute Myeloid Leukemia in Induction and Consolidation Chemotherapy without Bone Marrow Transplantation: Lessons Learned from Good Presentation Case Majalah Kedokteran Bandung Acute myeloid leukemia, chemotherapy, complete remission |
author_facet |
Tuti Sri Hastuti Rachmat Sumantri Indra Wijaya |
author_sort |
Tuti Sri Hastuti |
title |
Complete Remission of Acute Myeloid Leukemia in Induction and Consolidation Chemotherapy without Bone Marrow Transplantation: Lessons Learned from Good Presentation Case |
title_short |
Complete Remission of Acute Myeloid Leukemia in Induction and Consolidation Chemotherapy without Bone Marrow Transplantation: Lessons Learned from Good Presentation Case |
title_full |
Complete Remission of Acute Myeloid Leukemia in Induction and Consolidation Chemotherapy without Bone Marrow Transplantation: Lessons Learned from Good Presentation Case |
title_fullStr |
Complete Remission of Acute Myeloid Leukemia in Induction and Consolidation Chemotherapy without Bone Marrow Transplantation: Lessons Learned from Good Presentation Case |
title_full_unstemmed |
Complete Remission of Acute Myeloid Leukemia in Induction and Consolidation Chemotherapy without Bone Marrow Transplantation: Lessons Learned from Good Presentation Case |
title_sort |
complete remission of acute myeloid leukemia in induction and consolidation chemotherapy without bone marrow transplantation: lessons learned from good presentation case |
publisher |
Universitas Padjajaran |
series |
Majalah Kedokteran Bandung |
issn |
0126-074X 2338-6223 |
publishDate |
2019-03-01 |
description |
Acute myeloid leukemia (AML) is a clinically morphologically and genetically heterogeneous disease with variable responses to therapy. The majority of the patients eventually relapse and succumb to the disease. Therapeutic modalities of induction chemotherapy, consolidation, and bone marrow transplantation are intended to achieve complete remission. Induction therapy with cytarabine and anthracycline remains thestandard of care in AML. Consolidation treatment is necessary to prevent recurrence, which may reach 90% without this treatment. Options for consolidation therapy are conventional chemotherapy and bone marrow transplantation. Bone marrow transplantation represents the only realistic chance of long-term remission in patients with a high cytogenetic risk. The risk of recurrence of AML is determined mainly by the patient’s age and genetic factors. In younger patients, complete remission (CR) rates of ≥80% may be achieved, with 5-year overall survival (OS) of 40%. InDr. Hasan Sadikin Hospital Bandung during the period of 2013-2018, 12 cases of LMA underwent chemotherapy. This case study discusses a young patient with AML who has successfully reached complete remission using induction and consolidation chemotherapy without bone marrow transplantation.
Key words: Acute myeloid leukemia, chemotherapy, complete remission |
topic |
Acute myeloid leukemia, chemotherapy, complete remission |
url |
http://journal.fk.unpad.ac.id/index.php/mkb/article/view/1634 |
work_keys_str_mv |
AT tutisrihastuti completeremissionofacutemyeloidleukemiaininductionandconsolidationchemotherapywithoutbonemarrowtransplantationlessonslearnedfromgoodpresentationcase AT rachmatsumantri completeremissionofacutemyeloidleukemiaininductionandconsolidationchemotherapywithoutbonemarrowtransplantationlessonslearnedfromgoodpresentationcase AT indrawijaya completeremissionofacutemyeloidleukemiaininductionandconsolidationchemotherapywithoutbonemarrowtransplantationlessonslearnedfromgoodpresentationcase |
_version_ |
1724808602867204096 |