Neuroimaging of amblyopia and binocular vision: a review
Amblyopia is a cerebral visual impairment considered to derive from abnormal visual experience (e.g., strabismus, anisometropia). Amblyopia, first considered as a monocular disorder, is now often seen as a primarily binocular disorder resulting in more and more studies examining the binocular defici...
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doaj-570f8fb8459146799bbb878b548c14de2020-11-24T20:54:30ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452014-08-01810.3389/fnint.2014.0006288813Neuroimaging of amblyopia and binocular vision: a reviewOlivier eJoly0Olivier eJoly1Edit eFrankó2MRC Cognition and Brain Sciences UnitUniversity of OxfordUniversity College LondonAmblyopia is a cerebral visual impairment considered to derive from abnormal visual experience (e.g., strabismus, anisometropia). Amblyopia, first considered as a monocular disorder, is now often seen as a primarily binocular disorder resulting in more and more studies examining the binocular deficits in the patients. The neural mechanisms of amblyopia are not completely understood even though they have been investigated with electrophysiological recordings in animal models and more recently with neuroimaging techniques in humans. In this review, we summarise the current knowledge about the brain regions that underlie the visual deficits associated with amblyopia with a focus on binocular vision using functional magnetic resonance imaging (fMRI). The first studies focused on abnormal responses in the primary and secondary visual areas whereas recent evidence show that there are also deficits at higher levels of the visual pathways within the parieto-occipital and temporal cortices. These higher level areas are part of the cortical network involved in 3D vision from binocular cues. Therefore, reduced responses in these areas could be related to the impaired binocular vision in amblyopic patients. Promising new binocular treatments might at least partially correct the activation in these areas. Future neuroimaging experiments could help to characterise the brain response changes associated with these treatments and help devise them.http://journal.frontiersin.org/Journal/10.3389/fnint.2014.00062/fullAmblyopiaNeuroimagingVisual Cortexbinocular visionstereopsis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Olivier eJoly Olivier eJoly Edit eFrankó |
spellingShingle |
Olivier eJoly Olivier eJoly Edit eFrankó Neuroimaging of amblyopia and binocular vision: a review Frontiers in Integrative Neuroscience Amblyopia Neuroimaging Visual Cortex binocular vision stereopsis |
author_facet |
Olivier eJoly Olivier eJoly Edit eFrankó |
author_sort |
Olivier eJoly |
title |
Neuroimaging of amblyopia and binocular vision: a review |
title_short |
Neuroimaging of amblyopia and binocular vision: a review |
title_full |
Neuroimaging of amblyopia and binocular vision: a review |
title_fullStr |
Neuroimaging of amblyopia and binocular vision: a review |
title_full_unstemmed |
Neuroimaging of amblyopia and binocular vision: a review |
title_sort |
neuroimaging of amblyopia and binocular vision: a review |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Integrative Neuroscience |
issn |
1662-5145 |
publishDate |
2014-08-01 |
description |
Amblyopia is a cerebral visual impairment considered to derive from abnormal visual experience (e.g., strabismus, anisometropia). Amblyopia, first considered as a monocular disorder, is now often seen as a primarily binocular disorder resulting in more and more studies examining the binocular deficits in the patients. The neural mechanisms of amblyopia are not completely understood even though they have been investigated with electrophysiological recordings in animal models and more recently with neuroimaging techniques in humans. In this review, we summarise the current knowledge about the brain regions that underlie the visual deficits associated with amblyopia with a focus on binocular vision using functional magnetic resonance imaging (fMRI). The first studies focused on abnormal responses in the primary and secondary visual areas whereas recent evidence show that there are also deficits at higher levels of the visual pathways within the parieto-occipital and temporal cortices. These higher level areas are part of the cortical network involved in 3D vision from binocular cues. Therefore, reduced responses in these areas could be related to the impaired binocular vision in amblyopic patients. Promising new binocular treatments might at least partially correct the activation in these areas. Future neuroimaging experiments could help to characterise the brain response changes associated with these treatments and help devise them. |
topic |
Amblyopia Neuroimaging Visual Cortex binocular vision stereopsis |
url |
http://journal.frontiersin.org/Journal/10.3389/fnint.2014.00062/full |
work_keys_str_mv |
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