Improved Neural Processing Efficiency in a Chronic Aphasia Patient following Melodic Intonation Therapy: A Neuropsychological and Functional MRI Study
Melodic intonation therapy (MIT) is a treatment program for the rehabilitation of aphasic patients with speech production disorders. We report a case of severe chronic non-fluent aphasia unresponsive to several years of conventional therapy that showed a marked improvement following intensive nine-d...
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doaj-570fd6440f794dcd8daaae11846f2c9a2020-11-25T00:36:56ZengFrontiers Media S.A.Frontiers in Neurology1664-22952016-09-01710.3389/fneur.2016.00148205186Improved Neural Processing Efficiency in a Chronic Aphasia Patient following Melodic Intonation Therapy: A Neuropsychological and Functional MRI StudyKen-Ichi Tabei0Ken-Ichi Tabei1Masayuki Satoh2Chizuru Nakano3Ai Ito4Yasuo Shimoji5Hirotaka Kida6Hajime Sakuma7Hidekazu Tomimoto8Hidekazu Tomimoto9Graduate School of Medicine, Mie UniversityGraduate School of Medicine, Mie UniversityGraduate School of Medicine, Mie UniversityGraduate School of Medicine, Mie UniversityGraduate School of Medicine, Mie UniversitySuzuka Central General HospitalGraduate School of Medicine, Mie UniversityGraduate School of Medicine, Mie UniversityGraduate School of Medicine, Mie UniversityGraduate School of Medicine, Mie UniversityMelodic intonation therapy (MIT) is a treatment program for the rehabilitation of aphasic patients with speech production disorders. We report a case of severe chronic non-fluent aphasia unresponsive to several years of conventional therapy that showed a marked improvement following intensive nine-day training on the Japanese version of MIT (MIT-J). The purposes of this study were to verify the efficacy of MIT-J by functional assessment and examine associated changes in neural processing by functional magnetic resonance imaging. MIT improved language output and auditory comprehension, and decreased the response time for picture naming. Following MIT-J, an area of the right hemisphere was less activated on correct naming trials than compared to before training but similarly activated on incorrect trials. These results suggest that the aphasic symptoms of our patient were improved by increased neural processing efficiency and a concomitant decrease in cognitive load.http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00148/fullAphasiaProsodyWestern Aphasia Battery (WAB)neural efficiency theoryfunctional magnetic resonance imaging (MRI)Japanese version of MIT (MIT-J) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ken-Ichi Tabei Ken-Ichi Tabei Masayuki Satoh Chizuru Nakano Ai Ito Yasuo Shimoji Hirotaka Kida Hajime Sakuma Hidekazu Tomimoto Hidekazu Tomimoto |
spellingShingle |
Ken-Ichi Tabei Ken-Ichi Tabei Masayuki Satoh Chizuru Nakano Ai Ito Yasuo Shimoji Hirotaka Kida Hajime Sakuma Hidekazu Tomimoto Hidekazu Tomimoto Improved Neural Processing Efficiency in a Chronic Aphasia Patient following Melodic Intonation Therapy: A Neuropsychological and Functional MRI Study Frontiers in Neurology Aphasia Prosody Western Aphasia Battery (WAB) neural efficiency theory functional magnetic resonance imaging (MRI) Japanese version of MIT (MIT-J) |
author_facet |
Ken-Ichi Tabei Ken-Ichi Tabei Masayuki Satoh Chizuru Nakano Ai Ito Yasuo Shimoji Hirotaka Kida Hajime Sakuma Hidekazu Tomimoto Hidekazu Tomimoto |
author_sort |
Ken-Ichi Tabei |
title |
Improved Neural Processing Efficiency in a Chronic Aphasia Patient following Melodic Intonation Therapy: A Neuropsychological and Functional MRI Study |
title_short |
Improved Neural Processing Efficiency in a Chronic Aphasia Patient following Melodic Intonation Therapy: A Neuropsychological and Functional MRI Study |
title_full |
Improved Neural Processing Efficiency in a Chronic Aphasia Patient following Melodic Intonation Therapy: A Neuropsychological and Functional MRI Study |
title_fullStr |
Improved Neural Processing Efficiency in a Chronic Aphasia Patient following Melodic Intonation Therapy: A Neuropsychological and Functional MRI Study |
title_full_unstemmed |
Improved Neural Processing Efficiency in a Chronic Aphasia Patient following Melodic Intonation Therapy: A Neuropsychological and Functional MRI Study |
title_sort |
improved neural processing efficiency in a chronic aphasia patient following melodic intonation therapy: a neuropsychological and functional mri study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2016-09-01 |
description |
Melodic intonation therapy (MIT) is a treatment program for the rehabilitation of aphasic patients with speech production disorders. We report a case of severe chronic non-fluent aphasia unresponsive to several years of conventional therapy that showed a marked improvement following intensive nine-day training on the Japanese version of MIT (MIT-J). The purposes of this study were to verify the efficacy of MIT-J by functional assessment and examine associated changes in neural processing by functional magnetic resonance imaging. MIT improved language output and auditory comprehension, and decreased the response time for picture naming. Following MIT-J, an area of the right hemisphere was less activated on correct naming trials than compared to before training but similarly activated on incorrect trials. These results suggest that the aphasic symptoms of our patient were improved by increased neural processing efficiency and a concomitant decrease in cognitive load. |
topic |
Aphasia Prosody Western Aphasia Battery (WAB) neural efficiency theory functional magnetic resonance imaging (MRI) Japanese version of MIT (MIT-J) |
url |
http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00148/full |
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