Neonatal Lupus Erythematosus in a newborn with Citrullinemia
A 24-day-old female newborn presented with multiple annular erythematous plaques with a targetoid shape, on the forehead, neck and upper trunk, that had begun ten days earlier. She had been diagnosed with citrullinemia type 1 in the first week of life and arginine supplementation was initiated. Her...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Sociedade Portuguesa de Reumatologia
2018-07-01
|
Series: | Acta Reumatológica Portuguesa |
Subjects: | |
Online Access: | http://www.actareumatologica.pt/files/article/1217_neonatal_lupus_erythematosus_in_a_newborn_with_citrullinemia_file.pdf |
id |
doaj-571c842e9a8449a7a19a7ef6789a8c14 |
---|---|
record_format |
Article |
spelling |
doaj-571c842e9a8449a7a19a7ef6789a8c142020-11-25T02:49:55ZengSociedade Portuguesa de ReumatologiaActa Reumatológica Portuguesa0303-464X2018-07-0120183235236IR180071Neonatal Lupus Erythematosus in a newborn with CitrullinemiaRita Pimenta0Filipa Urbano1Luís Soares-de-Almeida2Sónia Fernandes3Hospital de Santa MariaHospital de Santa MariaHospital de Santa MariaHospital de Santa MariaA 24-day-old female newborn presented with multiple annular erythematous plaques with a targetoid shape, on the forehead, neck and upper trunk, that had begun ten days earlier. She had been diagnosed with citrullinemia type 1 in the first week of life and arginine supplementation was initiated. Her personal and family history was otherwise unremarkable. Laboratory tests showed high levels of anti-La/SSB and anti-Ro/SSA in both mother and baby. The patient was diagnosed with Neonatal lupus erythematosus on the basis of the clinical, histopathological and laboratorial findings. Neonatal lupus is a rare immune-mediated disease that results from transplacental transfer of maternal IgG antinuclear antibodies. The disease can affect different organs, mainly the skin and heart. Although the skin lesions are usually characteristic, they pose a diagnostic challenge in the absence of maternal history.http://www.actareumatologica.pt/files/article/1217_neonatal_lupus_erythematosus_in_a_newborn_with_citrullinemia_file.pdfCitrullinemianeonatal lupus erythematosuscutaneous manifestations |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rita Pimenta Filipa Urbano Luís Soares-de-Almeida Sónia Fernandes |
spellingShingle |
Rita Pimenta Filipa Urbano Luís Soares-de-Almeida Sónia Fernandes Neonatal Lupus Erythematosus in a newborn with Citrullinemia Acta Reumatológica Portuguesa Citrullinemia neonatal lupus erythematosus cutaneous manifestations |
author_facet |
Rita Pimenta Filipa Urbano Luís Soares-de-Almeida Sónia Fernandes |
author_sort |
Rita Pimenta |
title |
Neonatal Lupus Erythematosus in a newborn with Citrullinemia |
title_short |
Neonatal Lupus Erythematosus in a newborn with Citrullinemia |
title_full |
Neonatal Lupus Erythematosus in a newborn with Citrullinemia |
title_fullStr |
Neonatal Lupus Erythematosus in a newborn with Citrullinemia |
title_full_unstemmed |
Neonatal Lupus Erythematosus in a newborn with Citrullinemia |
title_sort |
neonatal lupus erythematosus in a newborn with citrullinemia |
publisher |
Sociedade Portuguesa de Reumatologia |
series |
Acta Reumatológica Portuguesa |
issn |
0303-464X |
publishDate |
2018-07-01 |
description |
A 24-day-old female newborn presented with multiple annular erythematous plaques with a targetoid shape, on the forehead, neck and upper trunk, that had begun ten days earlier. She had been diagnosed with citrullinemia type 1 in the first week of life and arginine supplementation was initiated. Her personal and family history was otherwise unremarkable. Laboratory tests showed high levels of anti-La/SSB and anti-Ro/SSA in both mother and baby. The patient was diagnosed with Neonatal lupus erythematosus on the basis of the clinical, histopathological and laboratorial findings. Neonatal lupus is a rare immune-mediated disease that results from transplacental transfer of maternal IgG antinuclear antibodies. The disease can affect different organs, mainly the skin and heart. Although the skin lesions are usually characteristic, they pose a diagnostic challenge in the absence of maternal history. |
topic |
Citrullinemia neonatal lupus erythematosus cutaneous manifestations |
url |
http://www.actareumatologica.pt/files/article/1217_neonatal_lupus_erythematosus_in_a_newborn_with_citrullinemia_file.pdf |
work_keys_str_mv |
AT ritapimenta neonatallupuserythematosusinanewbornwithcitrullinemia AT filipaurbano neonatallupuserythematosusinanewbornwithcitrullinemia AT luissoaresdealmeida neonatallupuserythematosusinanewbornwithcitrullinemia AT soniafernandes neonatallupuserythematosusinanewbornwithcitrullinemia |
_version_ |
1724741375427084288 |