MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review
Sepsis is a severe condition characterized by systemic inflammation. One of the most involved organs in sepsis is the heart. On the other hand, heart failure and dysfunction are some of the most leading causes of death in septic patients. miRNAs are short single-strand non-coding ribonucleic acids i...
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doaj-5729821e332146f4bf8edc705fcd83ef2020-12-31T00:04:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-012232132110.3390/ijms22010321MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic ReviewAlice Chiara Manetti0Aniello Maiese1Marco Di Paolo2Alessandra De Matteis3Raffaele La Russa4Emanuela Turillazzi5Paola Frati6Vittorio Fineschi7Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa (PI), ItalyDepartment of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa (PI), ItalyDepartment of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa (PI), ItalyDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome (RM), ItalyIRCSS Neuromed Mediterranean Neurological Institute, Via Atinense 18, 86077 Pozzilli (IS), ItalyDepartment of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa (PI), ItalyIRCSS Neuromed Mediterranean Neurological Institute, Via Atinense 18, 86077 Pozzilli (IS), ItalyIRCSS Neuromed Mediterranean Neurological Institute, Via Atinense 18, 86077 Pozzilli (IS), ItalySepsis is a severe condition characterized by systemic inflammation. One of the most involved organs in sepsis is the heart. On the other hand, heart failure and dysfunction are some of the most leading causes of death in septic patients. miRNAs are short single-strand non-coding ribonucleic acids involved in the regulation of gene expression on a post-transcriptional phase, which means they are a part of the epigenetic process. Recently, researchers have found that miRNA expression in tissues and blood differs depending on different conditions. Because of this property, their use as serum sepsis biomarkers has also been explored. A narrative review is carried out to gather and summarize what is known about miRNAs’ influence on cardiac dysfunction during sepsis. When reviewing the literature, we found at least 77 miRNAs involved in cardiac inflammation and dysfunction during sepsis. In the future, miRNAs may be used as early sepsis-induced cardiac dysfunction biomarkers or as new drug targets. This could help clinicians to early detect, prevent, and treat cardiac damage. The potential role of miRNAs as new diagnostic tools and therapeutic strategies worth deepening the complex network between non-coding RNA and biological pathways. Additional studies are needed to further investigate their role in sepsis-induced myocardium injury.https://www.mdpi.com/1422-0067/22/1/321sepsiscardiac dysfunctionmicroRNAmessenger RNAlong noncoding RNA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alice Chiara Manetti Aniello Maiese Marco Di Paolo Alessandra De Matteis Raffaele La Russa Emanuela Turillazzi Paola Frati Vittorio Fineschi |
spellingShingle |
Alice Chiara Manetti Aniello Maiese Marco Di Paolo Alessandra De Matteis Raffaele La Russa Emanuela Turillazzi Paola Frati Vittorio Fineschi MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review International Journal of Molecular Sciences sepsis cardiac dysfunction microRNA messenger RNA long noncoding RNA |
author_facet |
Alice Chiara Manetti Aniello Maiese Marco Di Paolo Alessandra De Matteis Raffaele La Russa Emanuela Turillazzi Paola Frati Vittorio Fineschi |
author_sort |
Alice Chiara Manetti |
title |
MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review |
title_short |
MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review |
title_full |
MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review |
title_fullStr |
MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review |
title_full_unstemmed |
MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review |
title_sort |
micrornas and sepsis-induced cardiac dysfunction: a systematic review |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-12-01 |
description |
Sepsis is a severe condition characterized by systemic inflammation. One of the most involved organs in sepsis is the heart. On the other hand, heart failure and dysfunction are some of the most leading causes of death in septic patients. miRNAs are short single-strand non-coding ribonucleic acids involved in the regulation of gene expression on a post-transcriptional phase, which means they are a part of the epigenetic process. Recently, researchers have found that miRNA expression in tissues and blood differs depending on different conditions. Because of this property, their use as serum sepsis biomarkers has also been explored. A narrative review is carried out to gather and summarize what is known about miRNAs’ influence on cardiac dysfunction during sepsis. When reviewing the literature, we found at least 77 miRNAs involved in cardiac inflammation and dysfunction during sepsis. In the future, miRNAs may be used as early sepsis-induced cardiac dysfunction biomarkers or as new drug targets. This could help clinicians to early detect, prevent, and treat cardiac damage. The potential role of miRNAs as new diagnostic tools and therapeutic strategies worth deepening the complex network between non-coding RNA and biological pathways. Additional studies are needed to further investigate their role in sepsis-induced myocardium injury. |
topic |
sepsis cardiac dysfunction microRNA messenger RNA long noncoding RNA |
url |
https://www.mdpi.com/1422-0067/22/1/321 |
work_keys_str_mv |
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