Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.
Corneal astigmatism refers to refractive abnormalities and irregularities in the curvature of the cornea, and this interferes with light being accurately focused at a single point in the eye. This ametropic condition is highly prevalent, influences visual acuity, and is a highly heritable trait. The...
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2011-12-01
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doaj-573e41a1bc30487ea7a89f0bf81976812020-11-24T22:05:32ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042011-12-01712e100240210.1371/journal.pgen.1002402Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.Qiao FanXin ZhouChiea-Chuen KhorChing-Yu ChengLiang-Kee GohXueling SimWan-Ting TayYi-Ju LiRick Twee-Hee OngChen SuoBelinda CornesMohammad Kamran IkramKee-Seng ChiaMark SeielstadJianjun LiuEranga VithanaTerri L YoungE-Shyong TaiTien-Yin WongTin AungYik-Ying TeoSeang-Mei SawCorneal astigmatism refers to refractive abnormalities and irregularities in the curvature of the cornea, and this interferes with light being accurately focused at a single point in the eye. This ametropic condition is highly prevalent, influences visual acuity, and is a highly heritable trait. There is currently a paucity of research in the genetic etiology of corneal astigmatism. Here we report the results from five genome-wide association studies of corneal astigmatism across three Asian populations, with an initial discovery set of 4,254 Chinese and Malay individuals consisting of 2,249 cases and 2,005 controls. Replication was obtained from three surveys comprising of 2,139 Indians, an additional 929 Chinese children, and an independent 397 Chinese family trios. Variants in PDGFRA on chromosome 4q12 (lead SNP: rs7677751, allelic odds ratio = 1.26 (95% CI: 1.16-1.36), P(meta) = 7.87×10(-9)) were identified to be significantly associated with corneal astigmatism, exhibiting consistent effect sizes across all five cohorts. This highlights the potential role of variants in PDGFRA in the genetic etiology of corneal astigmatism across diverse Asian populations.http://europepmc.org/articles/PMC3228826?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qiao Fan Xin Zhou Chiea-Chuen Khor Ching-Yu Cheng Liang-Kee Goh Xueling Sim Wan-Ting Tay Yi-Ju Li Rick Twee-Hee Ong Chen Suo Belinda Cornes Mohammad Kamran Ikram Kee-Seng Chia Mark Seielstad Jianjun Liu Eranga Vithana Terri L Young E-Shyong Tai Tien-Yin Wong Tin Aung Yik-Ying Teo Seang-Mei Saw |
spellingShingle |
Qiao Fan Xin Zhou Chiea-Chuen Khor Ching-Yu Cheng Liang-Kee Goh Xueling Sim Wan-Ting Tay Yi-Ju Li Rick Twee-Hee Ong Chen Suo Belinda Cornes Mohammad Kamran Ikram Kee-Seng Chia Mark Seielstad Jianjun Liu Eranga Vithana Terri L Young E-Shyong Tai Tien-Yin Wong Tin Aung Yik-Ying Teo Seang-Mei Saw Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. PLoS Genetics |
author_facet |
Qiao Fan Xin Zhou Chiea-Chuen Khor Ching-Yu Cheng Liang-Kee Goh Xueling Sim Wan-Ting Tay Yi-Ju Li Rick Twee-Hee Ong Chen Suo Belinda Cornes Mohammad Kamran Ikram Kee-Seng Chia Mark Seielstad Jianjun Liu Eranga Vithana Terri L Young E-Shyong Tai Tien-Yin Wong Tin Aung Yik-Ying Teo Seang-Mei Saw |
author_sort |
Qiao Fan |
title |
Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. |
title_short |
Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. |
title_full |
Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. |
title_fullStr |
Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. |
title_full_unstemmed |
Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. |
title_sort |
genome-wide meta-analysis of five asian cohorts identifies pdgfra as a susceptibility locus for corneal astigmatism. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Genetics |
issn |
1553-7390 1553-7404 |
publishDate |
2011-12-01 |
description |
Corneal astigmatism refers to refractive abnormalities and irregularities in the curvature of the cornea, and this interferes with light being accurately focused at a single point in the eye. This ametropic condition is highly prevalent, influences visual acuity, and is a highly heritable trait. There is currently a paucity of research in the genetic etiology of corneal astigmatism. Here we report the results from five genome-wide association studies of corneal astigmatism across three Asian populations, with an initial discovery set of 4,254 Chinese and Malay individuals consisting of 2,249 cases and 2,005 controls. Replication was obtained from three surveys comprising of 2,139 Indians, an additional 929 Chinese children, and an independent 397 Chinese family trios. Variants in PDGFRA on chromosome 4q12 (lead SNP: rs7677751, allelic odds ratio = 1.26 (95% CI: 1.16-1.36), P(meta) = 7.87×10(-9)) were identified to be significantly associated with corneal astigmatism, exhibiting consistent effect sizes across all five cohorts. This highlights the potential role of variants in PDGFRA in the genetic etiology of corneal astigmatism across diverse Asian populations. |
url |
http://europepmc.org/articles/PMC3228826?pdf=render |
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