When less is more: hormesis against stress and disease
All living organisms need to adapt to ever changing adverse conditions in order to survive. The phenomenon termed hormesis describes an evolutionarily conserved process by which a cell or an entire organism can be preconditioned, meaning that previous exposure to low doses of an insult protects agai...
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doaj-574043e9d4904a30beb1b85fcb4bd4522020-11-24T22:23:07ZengShared Science Publishers OGMicrobial Cell2311-26382014-05-011515015310.15698/mic2014.05.148When less is more: hormesis against stress and diseaseAndreas Zimmermann0Maria A. Bauer1Guido Kroemer2Frank Madeo3Didac Carmona-Gutierrez4Institute of Molecular Biosciences, University of Graz, Graz, Austria.Institute of Molecular Biosciences, University of Graz, Graz, Austria.INSERM, U848, Villejuif, France.Institute of Molecular Biosciences, University of Graz, Graz, Austria.Institute of Molecular Biosciences, University of Graz, Graz, Austria.All living organisms need to adapt to ever changing adverse conditions in order to survive. The phenomenon termed hormesis describes an evolutionarily conserved process by which a cell or an entire organism can be preconditioned, meaning that previous exposure to low doses of an insult protects against a higher, normally harmful or lethal dose of the same stressor. Growing evidence suggests that hormesis is directly linked to an organism’s (or cell’s) capability to cope with pathological conditions such as aging and age-related diseases. Here, we condense the conceptual and potentially therapeutic importance of hormesis by providing a short overview of current evidence in favor of the cytoprotective impact of hormesis, as well as of its underlying molecular mechanisms.http://microbialcell.com/researcharticles/when-less-is-more-hormesis-against-stress-and-disease/hormesisstress resistanceagingneurodegenerationtherapeutic preconditioning |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andreas Zimmermann Maria A. Bauer Guido Kroemer Frank Madeo Didac Carmona-Gutierrez |
spellingShingle |
Andreas Zimmermann Maria A. Bauer Guido Kroemer Frank Madeo Didac Carmona-Gutierrez When less is more: hormesis against stress and disease Microbial Cell hormesis stress resistance aging neurodegeneration therapeutic preconditioning |
author_facet |
Andreas Zimmermann Maria A. Bauer Guido Kroemer Frank Madeo Didac Carmona-Gutierrez |
author_sort |
Andreas Zimmermann |
title |
When less is more: hormesis against stress and disease |
title_short |
When less is more: hormesis against stress and disease |
title_full |
When less is more: hormesis against stress and disease |
title_fullStr |
When less is more: hormesis against stress and disease |
title_full_unstemmed |
When less is more: hormesis against stress and disease |
title_sort |
when less is more: hormesis against stress and disease |
publisher |
Shared Science Publishers OG |
series |
Microbial Cell |
issn |
2311-2638 |
publishDate |
2014-05-01 |
description |
All living organisms need to adapt to ever changing adverse conditions in order to survive. The phenomenon termed hormesis describes an evolutionarily conserved process by which a cell or an entire organism can be preconditioned, meaning that previous exposure to low doses of an insult protects against a higher, normally harmful or lethal dose of the same stressor. Growing evidence suggests that hormesis is directly linked to an organism’s (or cell’s) capability to cope with pathological conditions such as aging and age-related diseases. Here, we condense the conceptual and potentially therapeutic importance of hormesis by providing a short overview of current evidence in favor of the cytoprotective impact of hormesis, as well as of its underlying molecular mechanisms. |
topic |
hormesis stress resistance aging neurodegeneration therapeutic preconditioning |
url |
http://microbialcell.com/researcharticles/when-less-is-more-hormesis-against-stress-and-disease/ |
work_keys_str_mv |
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