GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression

GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression

Genetic factors contribute to peptic ulcer disease (PUD). Here, the authors perform a genome-wide association analysis on PUD in the UK Biobank, highlighting shared architecture with other gastrointestinal disorders and possible causal links with depression.

Bibliographic Details
Main Authors: Yeda Wu, Graham K. Murray, Enda M. Byrne, Julia Sidorenko, Peter M. Visscher, Naomi R. Wray
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21280-7
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spelling doaj-5741b558f57c49e99ab8db7f468bfa022021-02-21T12:12:04ZengNature Publishing GroupNature Communications2041-17232021-02-0112111710.1038/s41467-021-21280-7GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depressionYeda Wu0Graham K. Murray1Enda M. Byrne2Julia Sidorenko3Peter M. Visscher4Naomi R. Wray5Institute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandGenetic factors contribute to peptic ulcer disease (PUD). Here, the authors perform a genome-wide association analysis on PUD in the UK Biobank, highlighting shared architecture with other gastrointestinal disorders and possible causal links with depression.https://doi.org/10.1038/s41467-021-21280-7
collection DOAJ
language English
format Article
sources DOAJ
author Yeda Wu
Graham K. Murray
Enda M. Byrne
Julia Sidorenko
Peter M. Visscher
Naomi R. Wray
spellingShingle Yeda Wu
Graham K. Murray
Enda M. Byrne
Julia Sidorenko
Peter M. Visscher
Naomi R. Wray
GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression
Nature Communications
author_facet Yeda Wu
Graham K. Murray
Enda M. Byrne
Julia Sidorenko
Peter M. Visscher
Naomi R. Wray
author_sort Yeda Wu
title GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression
title_short GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression
title_full GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression
title_fullStr GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression
title_full_unstemmed GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression
title_sort gwas of peptic ulcer disease implicates helicobacter pylori infection, other gastrointestinal disorders and depression
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-02-01
description Genetic factors contribute to peptic ulcer disease (PUD). Here, the authors perform a genome-wide association analysis on PUD in the UK Biobank, highlighting shared architecture with other gastrointestinal disorders and possible causal links with depression.
url https://doi.org/10.1038/s41467-021-21280-7
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