Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemia

Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemia

ABSTRACT: During the coronavirus disease 2019 (COVID-19) pandemic, patients with humoral immunodeficiency are at higher risk of developing chronic infection and having a negative outcome. Few data are available on therapeutic options for this population. This case report discusses the treatment of d...

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Main Authors: Emanuele Palomba, Maria Carrabba, Gianluca Zuglian, Laura Alagna, Paola Saltini, Valeria Fortina, Cinzia Hu, Alessandra Bandera, Giovanna Fabio, Andrea Gori, Antonio Muscatello
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:International Journal of Infectious Diseases
Subjects:
SARS-CoV-2
COVID-19
Monoclonal antibodies
Neutralizing antibodies
Remdesivir
Casirivimab
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971221006196
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spelling doaj-5748f0355a18400692f82082450ce2472021-09-25T05:05:39ZengElsevierInternational Journal of Infectious Diseases1201-97122021-09-01110338340Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemiaEmanuele Palomba0Maria Carrabba1Gianluca Zuglian2Laura Alagna3Paola Saltini4Valeria Fortina5Cinzia Hu6Alessandra Bandera7Giovanna Fabio8Andrea Gori9Antonio Muscatello10Infectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Centre for Multidisciplinary Research in Health Science, University of Milan, Milan, Italy; Corresponding author. Address: Infectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, via Francesco Sforza, 35 - 20122 Milan, Italy. Tel.: +39 3494073517.Department of Internal Medicine, Rare Diseases Unit, Primary Immunodeficiencies Centre for Adults, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyInfectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyInfectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyInfectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Centre for Multidisciplinary Research in Health Science, University of Milan, Milan, ItalyInfectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Centre for Multidisciplinary Research in Health Science, University of Milan, Milan, ItalyDepartment of Internal Medicine, Rare Diseases Unit, Primary Immunodeficiencies Centre for Adults, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyInfectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Centre for Multidisciplinary Research in Health Science, University of Milan, Milan, ItalyDepartment of Internal Medicine, Rare Diseases Unit, Primary Immunodeficiencies Centre for Adults, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyInfectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Centre for Multidisciplinary Research in Health Science, University of Milan, Milan, ItalyInfectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyABSTRACT: During the coronavirus disease 2019 (COVID-19) pandemic, patients with humoral immunodeficiency are at higher risk of developing chronic infection and having a negative outcome. Few data are available on therapeutic options for this population. This case report discusses the treatment of disease relapse with remdesivir and monoclonal antibodies in an adult patient with X-linked agammaglobulinaemia.http://www.sciencedirect.com/science/article/pii/S1201971221006196SARS-CoV-2COVID-19Monoclonal antibodiesNeutralizing antibodiesRemdesivirCasirivimab
collection DOAJ
language English
format Article
sources DOAJ
author Emanuele Palomba
Maria Carrabba
Gianluca Zuglian
Laura Alagna
Paola Saltini
Valeria Fortina
Cinzia Hu
Alessandra Bandera
Giovanna Fabio
Andrea Gori
Antonio Muscatello
spellingShingle Emanuele Palomba
Maria Carrabba
Gianluca Zuglian
Laura Alagna
Paola Saltini
Valeria Fortina
Cinzia Hu
Alessandra Bandera
Giovanna Fabio
Andrea Gori
Antonio Muscatello
Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemia
International Journal of Infectious Diseases
SARS-CoV-2
COVID-19
Monoclonal antibodies
Neutralizing antibodies
Remdesivir
Casirivimab
author_facet Emanuele Palomba
Maria Carrabba
Gianluca Zuglian
Laura Alagna
Paola Saltini
Valeria Fortina
Cinzia Hu
Alessandra Bandera
Giovanna Fabio
Andrea Gori
Antonio Muscatello
author_sort Emanuele Palomba
title Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemia
title_short Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemia
title_full Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemia
title_fullStr Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemia
title_full_unstemmed Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemia
title_sort treatment of sars-cov-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with x-linked agammaglobulinaemia
publisher Elsevier
series International Journal of Infectious Diseases
issn 1201-9712
publishDate 2021-09-01
description ABSTRACT: During the coronavirus disease 2019 (COVID-19) pandemic, patients with humoral immunodeficiency are at higher risk of developing chronic infection and having a negative outcome. Few data are available on therapeutic options for this population. This case report discusses the treatment of disease relapse with remdesivir and monoclonal antibodies in an adult patient with X-linked agammaglobulinaemia.
topic SARS-CoV-2
COVID-19
Monoclonal antibodies
Neutralizing antibodies
Remdesivir
Casirivimab
url http://www.sciencedirect.com/science/article/pii/S1201971221006196
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