An Unexplored Pharmacologic/Diagnostic Strategy for Peri-Implantitis: A Protocol Proposal
Dental implants are widely utilized for the replacement of missing teeth and are increasingly being placed in patients with systemic diseases, as well as in those who are medically healthy. Furthermore, it is recognized that peri-implant mucositis and peri-implantitis are highly prevalent, affecting...
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doaj-574bc738006d4d18bc3ea3ee245ac6292020-12-06T00:01:28ZengMDPI AGDiagnostics2075-44182020-12-01101050105010.3390/diagnostics10121050An Unexplored Pharmacologic/Diagnostic Strategy for Peri-Implantitis: A Protocol ProposalLorne M. Golub0Ismo T. Räisänen1Timo Sorsa2Philip M. Preshaw3Department of Oral Biology and Pathology, School of Dental Medicine, Health Sciences Center, Stony Brook University, Stony Brook, NY 11794, USADepartment of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), FI-00014 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), FI-00014 Helsinki, FinlandNational University Centre for Oral Health, Faculty of Dentistry, National University of Singapore, Singapore 119077, SingaporeDental implants are widely utilized for the replacement of missing teeth and are increasingly being placed in patients with systemic diseases, as well as in those who are medically healthy. Furthermore, it is recognized that peri-implant mucositis and peri-implantitis are highly prevalent, affecting large numbers of patients with implants, and it is pertinent to consider whether there may be any systemic impact of these conditions, given that there are known links between periodontitis and a number of chronic inflammatory diseases. In this article, we propose that the potential systemic complications of peri-implant diseases should be investigated in future clinical research, together with studies to identify whether systemically-administered host modulation therapies (HMTs) may be of benefit in the treatment of peri-implant diseases. These “HMTs” may prove a useful adjunct to routinely employed debridement and disinfection protocols, as well as potentially being of benefit in reducing risks of systemic complications. We also consider the use of chair-side diagnostic tests for active matrix metalloproteinase-8 (aMMP-8) in the detection of peri-implant disease given the ability of such tests to detect active tissue breakdown associated with peri-implantitis and periodontitis before conventional clinical and radiographic measurements indicate pathologic changes. These novel diagnostic and therapeutic strategies are relevant to consider as they may improve the management of peri-implant disease (beyond local debridement procedures), especially in those patients in whom systemic inflammation might be of concern.https://www.mdpi.com/2075-4418/10/12/1050dental implantsperi-implant mucositisperi-implantitisperiodontitishost modulation therapiesmatrix metalloproteinases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lorne M. Golub Ismo T. Räisänen Timo Sorsa Philip M. Preshaw |
spellingShingle |
Lorne M. Golub Ismo T. Räisänen Timo Sorsa Philip M. Preshaw An Unexplored Pharmacologic/Diagnostic Strategy for Peri-Implantitis: A Protocol Proposal Diagnostics dental implants peri-implant mucositis peri-implantitis periodontitis host modulation therapies matrix metalloproteinases |
author_facet |
Lorne M. Golub Ismo T. Räisänen Timo Sorsa Philip M. Preshaw |
author_sort |
Lorne M. Golub |
title |
An Unexplored Pharmacologic/Diagnostic Strategy for Peri-Implantitis: A Protocol Proposal |
title_short |
An Unexplored Pharmacologic/Diagnostic Strategy for Peri-Implantitis: A Protocol Proposal |
title_full |
An Unexplored Pharmacologic/Diagnostic Strategy for Peri-Implantitis: A Protocol Proposal |
title_fullStr |
An Unexplored Pharmacologic/Diagnostic Strategy for Peri-Implantitis: A Protocol Proposal |
title_full_unstemmed |
An Unexplored Pharmacologic/Diagnostic Strategy for Peri-Implantitis: A Protocol Proposal |
title_sort |
unexplored pharmacologic/diagnostic strategy for peri-implantitis: a protocol proposal |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2020-12-01 |
description |
Dental implants are widely utilized for the replacement of missing teeth and are increasingly being placed in patients with systemic diseases, as well as in those who are medically healthy. Furthermore, it is recognized that peri-implant mucositis and peri-implantitis are highly prevalent, affecting large numbers of patients with implants, and it is pertinent to consider whether there may be any systemic impact of these conditions, given that there are known links between periodontitis and a number of chronic inflammatory diseases. In this article, we propose that the potential systemic complications of peri-implant diseases should be investigated in future clinical research, together with studies to identify whether systemically-administered host modulation therapies (HMTs) may be of benefit in the treatment of peri-implant diseases. These “HMTs” may prove a useful adjunct to routinely employed debridement and disinfection protocols, as well as potentially being of benefit in reducing risks of systemic complications. We also consider the use of chair-side diagnostic tests for active matrix metalloproteinase-8 (aMMP-8) in the detection of peri-implant disease given the ability of such tests to detect active tissue breakdown associated with peri-implantitis and periodontitis before conventional clinical and radiographic measurements indicate pathologic changes. These novel diagnostic and therapeutic strategies are relevant to consider as they may improve the management of peri-implant disease (beyond local debridement procedures), especially in those patients in whom systemic inflammation might be of concern. |
topic |
dental implants peri-implant mucositis peri-implantitis periodontitis host modulation therapies matrix metalloproteinases |
url |
https://www.mdpi.com/2075-4418/10/12/1050 |
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