Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology

Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology

Mitochondrial dysfunction plays a pivotal role in the progression of Alzheimer's disease (AD), and yet the mechanisms underlying the impairment of mitochondrial function in AD remain elusive. Recent evidence suggested a role for Presenilins (PS1 or PS2) in mitochondrial function. Mutations of P...

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Bibliographic Details
Main Authors: Sabrina Contino, Paolo E. Porporato, Matthew Bird, Claudia Marinangeli, Rémi Opsomer, Pierre Sonveaux, Françoise Bontemps, Ilse Dewachter, Jean-Noël Octave, Luc Bertrand, Serena Stanga, Pascal Kienlen-Campard
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Physiology
Subjects:
presenilin
mitochondria
glycolysis
oxidative phosphorylation
cellular bioenergetics
Alzheimer's disease
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00796/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00796/full

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