Tumor-associated macrophages, potential targets for cancer treatment

Abstract The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now begin...

Full description

Bibliographic Details
Main Authors:	Li Yang, Yi Zhang
Format:	Article
Language:	English
Published:	BMC 2017-08-01
Series:	Biomarker Research
Subjects:	Tumor-associated macrophages (TAMs) Tumor microenvironment Therapeutic target Cancer treatment Protumoral activities
Online Access:	http://link.springer.com/article/10.1186/s40364-017-0106-7

id	doaj-5751fea86422420d93b650c3f506647b
record_format	Article
spelling	doaj-5751fea86422420d93b650c3f506647b2020-11-25T00:39:56ZengBMCBiomarker Research2050-77712017-08-01511610.1186/s40364-017-0106-7Tumor-associated macrophages, potential targets for cancer treatmentLi Yang0Yi Zhang1Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou UniversityBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou UniversityAbstract The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as “protumoral macrophages”, contributing to disease progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential therapeutic targets in these cases. In this review, we will discuss how TAMs can be used as therapeutic targets of cancer in clinics.http://link.springer.com/article/10.1186/s40364-017-0106-7Tumor-associated macrophages (TAMs)Tumor microenvironmentTherapeutic targetCancer treatmentProtumoral activities
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Li Yang Yi Zhang
spellingShingle	Li Yang Yi Zhang Tumor-associated macrophages, potential targets for cancer treatment Biomarker Research Tumor-associated macrophages (TAMs) Tumor microenvironment Therapeutic target Cancer treatment Protumoral activities
author_facet	Li Yang Yi Zhang
author_sort	Li Yang
title	Tumor-associated macrophages, potential targets for cancer treatment
title_short	Tumor-associated macrophages, potential targets for cancer treatment
title_full	Tumor-associated macrophages, potential targets for cancer treatment
title_fullStr	Tumor-associated macrophages, potential targets for cancer treatment
title_full_unstemmed	Tumor-associated macrophages, potential targets for cancer treatment
title_sort	tumor-associated macrophages, potential targets for cancer treatment
publisher	BMC
series	Biomarker Research
issn	2050-7771
publishDate	2017-08-01
description	Abstract The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as “protumoral macrophages”, contributing to disease progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential therapeutic targets in these cases. In this review, we will discuss how TAMs can be used as therapeutic targets of cancer in clinics.
topic	Tumor-associated macrophages (TAMs) Tumor microenvironment Therapeutic target Cancer treatment Protumoral activities
url	http://link.springer.com/article/10.1186/s40364-017-0106-7
work_keys_str_mv	AT liyang tumorassociatedmacrophagespotentialtargetsforcancertreatment AT yizhang tumorassociatedmacrophagespotentialtargetsforcancertreatment
_version_	1725292397420609536

Tumor-associated macrophages, potential targets for cancer treatment

Similar Items