Effects of FuFangDanShenDiWan on cell adhesion molecules, endothelin and platelet aggregation rate in senile patients with carotid atherosclerosis
Objective: To observe the effects of FuFangDanShenDiWan on cell adhesion molecules, inflammatory response factors and endothelin in senile patients with carotid atherosclerosis. Methods From January 2017 to November 2018, 106 patients with carotid atherosclerosis sampled from a hospital were sele...
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doaj-5761b0b125e9474087bbd2bc168edfb72020-11-24T23:48:47ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372019-09-0125195559Effects of FuFangDanShenDiWan on cell adhesion molecules, endothelin and platelet aggregation rate in senile patients with carotid atherosclerosisLUO Hua0LV Hai-Yang1Pharmacy Department, Shuguang Hospital Affiliated To Shanghai University of TCM, Shanghai 200021, ChinaLV Hai-YangObjective: To observe the effects of FuFangDanShenDiWan on cell adhesion molecules, inflammatory response factors and endothelin in senile patients with carotid atherosclerosis. Methods From January 2017 to November 2018, 106 patients with carotid atherosclerosis sampled from a hospital were selected as the research objects. All patients included in this study were divided into Compound Danshen Dripping Pill group and western medicine group according to the order of visit. Patients in the western medicine group were given routine treatment and calcium atorvastatin. Compound Danshen Dripping Pill group was given Compound Danshen Dripping Pill on the basis of the treatment of control group. The changes of soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), monocyte chemotactic protein-l (MCP-1), tumor necrosis factor (TNF-actor (TNF--or (TNF-ic protein-l (MCP-1hs-CRP), nitric oxide (NO), endothelin (ET), platelet maximum aggregation rate (PAGM), and thrombin B2 (TXB2) were compared between the two groups before and after treatment. Results The level of cell adhesion molecules, inflammatory response factors, NO, ET, PAGM, TXB2 were not statistically significant between the two groups before treatment (P>0.05). After 6 courses of treatment, the level of sICAM-1, sVCAM-1, MCP-1, TNF-1, hs-CRP, ET, PAGM, TXB2 of patients in the FuFangDanShenDiWan group and western medicine group were significantly lower than those before treatment (P<0.05). The level of sICAM-1, sVCAM-1, MCP-1, TNF-M, hs-CRP, ET, PAGM, TXB2 in Compound Danshen Dripping Pill group were significantly lower than those in western medicine group (P<0.05). The levels of NO in the FuFangDanShenDiWan group and western medicine group was significantly higher than that before treatment (P<0.05). In addition, The levels of NO in the Compound Danshen Dripping Pill group was significantly higher than that in the western medicine group (P<0.05). Conclusion Compound Danshen Dripping Pill assisted atorvastatin calcium in the treatment of senile carotid atherosclerosis has a significant effect. Taking Compound Danshen Dripping Pill can effectively reduce the inflammatory reaction of the body of senile carotid atherosclerosis patients, regulate the expression of immune cell adhesion molecules, have a positive effect on the endothelial function and platelet function of patients, reduce the formation of thrombosis, and effectively alleviate the progression of senile carotid atherosclerosis.http://www.hnykdxxb.com/PDF/201917/12.pdf carotid atherosclerosiscompound danshen dripping pillsenior citizenatorvastatin calcium |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
LUO Hua LV Hai-Yang |
spellingShingle |
LUO Hua LV Hai-Yang Effects of FuFangDanShenDiWan on cell adhesion molecules, endothelin and platelet aggregation rate in senile patients with carotid atherosclerosis Journal of Hainan Medical University carotid atherosclerosis compound danshen dripping pill senior citizen atorvastatin calcium |
author_facet |
LUO Hua LV Hai-Yang |
author_sort |
LUO Hua |
title |
Effects of FuFangDanShenDiWan on cell adhesion molecules, endothelin and platelet aggregation rate in senile patients with carotid atherosclerosis |
title_short |
Effects of FuFangDanShenDiWan on cell adhesion molecules, endothelin and platelet aggregation rate in senile patients with carotid atherosclerosis |
title_full |
Effects of FuFangDanShenDiWan on cell adhesion molecules, endothelin and platelet aggregation rate in senile patients with carotid atherosclerosis |
title_fullStr |
Effects of FuFangDanShenDiWan on cell adhesion molecules, endothelin and platelet aggregation rate in senile patients with carotid atherosclerosis |
title_full_unstemmed |
Effects of FuFangDanShenDiWan on cell adhesion molecules, endothelin and platelet aggregation rate in senile patients with carotid atherosclerosis |
title_sort |
effects of fufangdanshendiwan on cell adhesion molecules, endothelin and platelet aggregation rate in senile patients with carotid atherosclerosis |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2019-09-01 |
description |
Objective: To observe the effects of FuFangDanShenDiWan on cell adhesion molecules,
inflammatory response factors and endothelin in senile patients with carotid atherosclerosis.
Methods From January 2017 to November 2018, 106 patients with carotid atherosclerosis
sampled from a hospital were selected as the research objects. All patients included in this
study were divided into Compound Danshen Dripping Pill group and western medicine
group according to the order of visit. Patients in the western medicine group were given
routine treatment and calcium atorvastatin. Compound Danshen Dripping Pill group was
given Compound Danshen Dripping Pill on the basis of the treatment of control group.
The changes of soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell
adhesion molecule 1 (sVCAM-1), monocyte chemotactic protein-l (MCP-1), tumor necrosis
factor (TNF-actor (TNF--or (TNF-ic protein-l (MCP-1hs-CRP), nitric oxide (NO), endothelin
(ET), platelet maximum aggregation rate (PAGM), and thrombin B2 (TXB2) were compared
between the two groups before and after treatment. Results The level of cell adhesion
molecules, inflammatory response factors, NO, ET, PAGM, TXB2 were not statistically
significant between the two groups before treatment (P>0.05). After 6 courses of treatment, the
level of sICAM-1, sVCAM-1, MCP-1, TNF-1, hs-CRP, ET, PAGM, TXB2 of patients in the
FuFangDanShenDiWan group and western medicine group were significantly lower than those
before treatment (P<0.05). The level of sICAM-1, sVCAM-1, MCP-1, TNF-M, hs-CRP, ET,
PAGM, TXB2 in Compound Danshen Dripping Pill group were significantly lower than those
in western medicine group (P<0.05). The levels of NO in the FuFangDanShenDiWan group
and western medicine group was significantly higher than that before treatment (P<0.05). In
addition, The levels of NO in the Compound Danshen Dripping Pill group was significantly
higher than that in the western medicine group (P<0.05). Conclusion Compound Danshen
Dripping Pill assisted atorvastatin calcium in the treatment of senile carotid atherosclerosis
has a significant effect. Taking Compound Danshen Dripping Pill can effectively reduce
the inflammatory reaction of the body of senile carotid atherosclerosis patients, regulate
the expression of immune cell adhesion molecules, have a positive effect on the endothelial
function and platelet function of patients, reduce the formation of thrombosis, and effectively
alleviate the progression of senile carotid atherosclerosis. |
topic |
carotid atherosclerosis compound danshen dripping pill senior citizen atorvastatin calcium |
url |
http://www.hnykdxxb.com/PDF/201917/12.pdf |
work_keys_str_mv |
AT luohua effectsoffufangdanshendiwanoncelladhesionmoleculesendothelinandplateletaggregationrateinsenilepatientswithcarotidatherosclerosis AT lvhaiyang effectsoffufangdanshendiwanoncelladhesionmoleculesendothelinandplateletaggregationrateinsenilepatientswithcarotidatherosclerosis |
_version_ |
1725484512787300352 |