ERP markers are associated with neurodevelopmental outcomes in 1–5 month old infants in rural Africa and the UK

• Main Authors: Laura Katus, Luke Mason, Bosiljka Milosavljevic, Samantha McCann, Maria Rozhko, Sophie E. Moore, Clare E. Elwell, Sarah Lloyd-Fox, Michelle de Haan, Saikou Drammeh, Ebrima Mbye, Ebou Touray, Mohammed Ceesay, Buba Jobarteh, Momodou K. Darboe, Topun Austin, Andrew Prentice
• Format: Article
• Language: English
• Published: Elsevier 2020-04-01
• Series: NeuroImage
• Subjects: Neurodevelopment; Global health; Infants; Event related potentials; Novelty detection; Habituation
• Online Access: http://www.sciencedirect.com/science/article/pii/S1053811920300781

Introduction: Infants and children in low- and middle-income countries are frequently exposed to a range of poverty-related risk factors, increasing their likelihood of poor neurodevelopmental outcomes. There is a need for culturally objective markers, which can be used to study infants from birth, thereby enabling early identification and ultimately intervention during a critical time of neurodevelopment. Method: In this paper, we investigate developmental changes in auditory event related potentials (ERP) associated with habituation and novelty detection in infants between 1 and 5 months living in the United Kingdom and The Gambia, West Africa. Previous research reports that whereas newborns’ ERP responses are increased when presented with stimuli of higher intensity, this sensory driven response decreases over the first few months of life, giving rise to a cognitively driven, novelty-based response. Anthropometric measures were obtained concurrently with the ERP measures at 1 and 5 months of age. Neurodevelopmental outcome was measured using the Mullen Scales of Early Learning (MSEL) at 5 months of age. Results: The described developmental change was observed in the UK cohort, who exhibited an intensity-based response at 1 month and a novelty-based response at 5 months of age. This change was accompanied by greater habituation to stimulus intensity at 5 compared to 1 month. In the Gambian cohort we did not see a change from an intensity-to a novelty-based response, and no change in habituation to stimulus intensity across the two age points. The degree of change from an intensity towards a novelty-based response was further found to be associated with MSEL scores at 5 months of infant age, whereas infants’ growth between 1 and 5 months was not. Discussion: Our study highlights the utility of ERP-based markers to study young infants in rural Africa. By implementing a well-established paradigm in a previously understudied population we have demonstrated its use as a culturally objective tool to better understand early learning in diverse settings world-wide. Results offer insight into the neurodevelopmental processes underpinning early neurocognitive development, which may in the future contribute to early identification of infants at heightened risk of adverse neurodevelopmental outcome.