Functional peptide KP24 enhances submandibular gland tissue growth in vitro

Introduction: Salivary gland hypofunction, also known as xerostomia, occurs as a result of radiotherapy for head and neck cancer, autoimmune diseases, or aging. Xerostomia leads to oral health problems and thus affects the quality of life. Biological salivary gland tissue generated in vitro would pr...

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Main Authors:	Atsushi Ikeda, Hiroaki Taketa, Gulsan Ara Sathi, Yoshiaki Hirano, Seiji Iida, Takuya Matsumoto
Format:	Article
Language:	English
Published:	Elsevier 2016-03-01
Series:	Regenerative Therapy
Subjects:	Submandibular gland Tissue manipulation Functional peptide Hydrogel
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352320416000195

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spelling	doaj-5784d9353e1f4659ae22140fa169ee902020-11-24T22:16:28ZengElsevierRegenerative Therapy2352-32042016-03-013C10811310.1016/j.reth.2016.02.006Functional peptide KP24 enhances submandibular gland tissue growth in vitroAtsushi Ikeda0Hiroaki Taketa1Gulsan Ara Sathi2Yoshiaki Hirano3Seiji Iida4Takuya Matsumoto5Department of Biomaterials, Okayama University, 2-5-1 Shikata-Cho, Okayama, 700-8558, JapanDepartment of Biomaterials, Okayama University, 2-5-1 Shikata-Cho, Okayama, 700-8558, JapanDepartment of Biomaterials, Okayama University, 2-5-1 Shikata-Cho, Okayama, 700-8558, JapanDepartment of Chemical Engineering, Kansai University, 3-3-1 Yamate, Suita 564-8680, JapanDepartment of Oral and Maxillofacial Reconstructive Surgery, Okayama University, 2-5-1 Shikata-Cho, Okayama, 700-8558, JapanDepartment of Biomaterials, Okayama University, 2-5-1 Shikata-Cho, Okayama, 700-8558, JapanIntroduction: Salivary gland hypofunction, also known as xerostomia, occurs as a result of radiotherapy for head and neck cancer, autoimmune diseases, or aging. Xerostomia leads to oral health problems and thus affects the quality of life. Biological salivary gland tissue generated in vitro would provide an alternative mode of treatment for this disease. Methods: To develop a novel method for modulating salivary gland tissue growth in vitro, we prepared a KP24 peptide-immobilized hydrogel sheet, wherein the peptide comprised repeating proline and lysine sequences, and evaluated the effect of this peptide on salivary gland tissue growth. Results: We found that the KP24 peptide has the potential to enhance glandular tissue growth in vitro. This enhancement is associated with neurite outgrowth and increasing neural innervation. Conclusion: KP24 peptide modified material would be a promising material for the modulation of salivary gland tissue growth in vitro.http://www.sciencedirect.com/science/article/pii/S2352320416000195Submandibular glandTissue manipulationFunctional peptideHydrogel
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Atsushi Ikeda Hiroaki Taketa Gulsan Ara Sathi Yoshiaki Hirano Seiji Iida Takuya Matsumoto
spellingShingle	Atsushi Ikeda Hiroaki Taketa Gulsan Ara Sathi Yoshiaki Hirano Seiji Iida Takuya Matsumoto Functional peptide KP24 enhances submandibular gland tissue growth in vitro Regenerative Therapy Submandibular gland Tissue manipulation Functional peptide Hydrogel
author_facet	Atsushi Ikeda Hiroaki Taketa Gulsan Ara Sathi Yoshiaki Hirano Seiji Iida Takuya Matsumoto
author_sort	Atsushi Ikeda
title	Functional peptide KP24 enhances submandibular gland tissue growth in vitro
title_short	Functional peptide KP24 enhances submandibular gland tissue growth in vitro
title_full	Functional peptide KP24 enhances submandibular gland tissue growth in vitro
title_fullStr	Functional peptide KP24 enhances submandibular gland tissue growth in vitro
title_full_unstemmed	Functional peptide KP24 enhances submandibular gland tissue growth in vitro
title_sort	functional peptide kp24 enhances submandibular gland tissue growth in vitro
publisher	Elsevier
series	Regenerative Therapy
issn	2352-3204
publishDate	2016-03-01
description	Introduction: Salivary gland hypofunction, also known as xerostomia, occurs as a result of radiotherapy for head and neck cancer, autoimmune diseases, or aging. Xerostomia leads to oral health problems and thus affects the quality of life. Biological salivary gland tissue generated in vitro would provide an alternative mode of treatment for this disease. Methods: To develop a novel method for modulating salivary gland tissue growth in vitro, we prepared a KP24 peptide-immobilized hydrogel sheet, wherein the peptide comprised repeating proline and lysine sequences, and evaluated the effect of this peptide on salivary gland tissue growth. Results: We found that the KP24 peptide has the potential to enhance glandular tissue growth in vitro. This enhancement is associated with neurite outgrowth and increasing neural innervation. Conclusion: KP24 peptide modified material would be a promising material for the modulation of salivary gland tissue growth in vitro.
topic	Submandibular gland Tissue manipulation Functional peptide Hydrogel
url	http://www.sciencedirect.com/science/article/pii/S2352320416000195
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Functional peptide KP24 enhances submandibular gland tissue growth in vitro

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