Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass
Background: A large body of evidence has shown a link between arsenic exposure and diabetes, but the underlying mechanisms have not yet been clarified. Objective: We explored the association between arsenic exposure and the reduction of skeletal muscle mass as a potential mechanism of insulin resist...
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Elsevier
2020-10-01
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Series: | Environment International |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412020318456 |
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doaj-578756f61720434692df7dc154ac7e55 |
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record_format |
Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Victor Mondal Zubaer Hosen Faruk Hossen Abu Eabrahim Siddique Selim Reza Tony Zohurul Islam Md. Shofikul Islam Shakhawoat Hossain Khairul Islam Md. Khalequzzaman Sarker M.M. Hasibuzzaman Ling-Zhi Liu Bing-Hua Jiang Md Mominul Hoque Zahangir Alam Saud Lian Xin Seiichiro Himeno Khaled Hossain |
spellingShingle |
Victor Mondal Zubaer Hosen Faruk Hossen Abu Eabrahim Siddique Selim Reza Tony Zohurul Islam Md. Shofikul Islam Shakhawoat Hossain Khairul Islam Md. Khalequzzaman Sarker M.M. Hasibuzzaman Ling-Zhi Liu Bing-Hua Jiang Md Mominul Hoque Zahangir Alam Saud Lian Xin Seiichiro Himeno Khaled Hossain Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass Environment International Arsenic Diabetes Bangladesh Hyperglycemia Insulin resistance Muscle mass |
author_facet |
Victor Mondal Zubaer Hosen Faruk Hossen Abu Eabrahim Siddique Selim Reza Tony Zohurul Islam Md. Shofikul Islam Shakhawoat Hossain Khairul Islam Md. Khalequzzaman Sarker M.M. Hasibuzzaman Ling-Zhi Liu Bing-Hua Jiang Md Mominul Hoque Zahangir Alam Saud Lian Xin Seiichiro Himeno Khaled Hossain |
author_sort |
Victor Mondal |
title |
Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass |
title_short |
Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass |
title_full |
Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass |
title_fullStr |
Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass |
title_full_unstemmed |
Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass |
title_sort |
arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2020-10-01 |
description |
Background: A large body of evidence has shown a link between arsenic exposure and diabetes, but the underlying mechanisms have not yet been clarified. Objective: We explored the association between arsenic exposure and the reduction of skeletal muscle mass as a potential mechanism of insulin resistance for developing arsenic-related hyperglycemia. Methods: A total of 581 subjects were recruited from arsenic-endemic and non-endemic areas in Bangladesh and their fasting blood glucose (FBG), serum insulin, and serum creatinine levels were determined. Subjects’ arsenic exposure levels were assessed by arsenic concentrations in water, hair, and nails. HOMA-IR and HOMA-β were used to calculate insulin resistance and β-cell dysfunction, respectively. Serum creatinine levels and lean body mass (LBM) were used as muscle mass indicators. Results: Water, hair and nail arsenic concentrations showed significant positive associations with FBG, serum insulin and HOMA-IR and inverse associations with serum creatinine and LBM in a dose-dependent manner both in males and females. Water, hair and nail arsenic showed significant inverse associations with HOMA-β in females but not in males. FBG and HOMA-IR were increased with the decreasing levels of serum creatinine and LBM. Odds ratios (ORs) of hyperglycemia were significantly increased with the increasing concentrations of arsenic in water, hair and nails and with the decreasing levels of serum creatinine and LBM. Females’ HOMA-IR showed greater susceptibility to the reduction of serum creatinine and LBM, possibly causing the greater risk of hyperglycemia in females than males. Path analysis revealed the mediating effect of serum creatinine level on the relationship of arsenic exposure with HOMA-IR and hyperglycemia. Conclusion: Arsenic exposure elevates FBG levels and the risk of hyperglycemia through increasing insulin resistance with greater susceptibility in females than males. Additionally, arsenic exposure-related reduction of skeletal muscle mass may be a mechanism underlying the development of insulin resistance and hyperglycemia. |
topic |
Arsenic Diabetes Bangladesh Hyperglycemia Insulin resistance Muscle mass |
url |
http://www.sciencedirect.com/science/article/pii/S0160412020318456 |
work_keys_str_mv |
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doaj-578756f61720434692df7dc154ac7e552020-11-25T03:23:51ZengElsevierEnvironment International0160-41202020-10-01143105890Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle massVictor Mondal0Zubaer Hosen1Faruk Hossen2Abu Eabrahim Siddique3Selim Reza Tony4Zohurul Islam5Md. Shofikul Islam6Shakhawoat Hossain7Khairul Islam8Md. Khalequzzaman Sarker9M.M. Hasibuzzaman10Ling-Zhi Liu11Bing-Hua Jiang12Md Mominul Hoque13Zahangir Alam Saud14Lian Xin15Seiichiro Himeno16Khaled Hossain17Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Applied Nutrition and Food Technology, Islamic University, Kushtia 7003, BangladeshDepartment of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Applied Nutrition and Food Technology, Islamic University, Kushtia 7003, BangladeshDepartment of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Biochemistry and Molecular Biology, Mawlana Bhashani Science & Technology University, Tangail 1902, BangladeshDepartment of Gastroenterology, Rajshahi Medical College, Rajshahi 6000, BangladeshInterdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, United StatesDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United StatesDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United StatesDepartment of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshLaboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770–8514, JapanLaboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770–8514, JapanDepartment of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh; Corresponding author: Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi 6205, Bangladesh.Background: A large body of evidence has shown a link between arsenic exposure and diabetes, but the underlying mechanisms have not yet been clarified. Objective: We explored the association between arsenic exposure and the reduction of skeletal muscle mass as a potential mechanism of insulin resistance for developing arsenic-related hyperglycemia. Methods: A total of 581 subjects were recruited from arsenic-endemic and non-endemic areas in Bangladesh and their fasting blood glucose (FBG), serum insulin, and serum creatinine levels were determined. Subjects’ arsenic exposure levels were assessed by arsenic concentrations in water, hair, and nails. HOMA-IR and HOMA-β were used to calculate insulin resistance and β-cell dysfunction, respectively. Serum creatinine levels and lean body mass (LBM) were used as muscle mass indicators. Results: Water, hair and nail arsenic concentrations showed significant positive associations with FBG, serum insulin and HOMA-IR and inverse associations with serum creatinine and LBM in a dose-dependent manner both in males and females. Water, hair and nail arsenic showed significant inverse associations with HOMA-β in females but not in males. FBG and HOMA-IR were increased with the decreasing levels of serum creatinine and LBM. Odds ratios (ORs) of hyperglycemia were significantly increased with the increasing concentrations of arsenic in water, hair and nails and with the decreasing levels of serum creatinine and LBM. Females’ HOMA-IR showed greater susceptibility to the reduction of serum creatinine and LBM, possibly causing the greater risk of hyperglycemia in females than males. Path analysis revealed the mediating effect of serum creatinine level on the relationship of arsenic exposure with HOMA-IR and hyperglycemia. Conclusion: Arsenic exposure elevates FBG levels and the risk of hyperglycemia through increasing insulin resistance with greater susceptibility in females than males. Additionally, arsenic exposure-related reduction of skeletal muscle mass may be a mechanism underlying the development of insulin resistance and hyperglycemia.http://www.sciencedirect.com/science/article/pii/S0160412020318456ArsenicDiabetesBangladeshHyperglycemiaInsulin resistanceMuscle mass |