Mitochondrial Disease and Anesthesia

Mitochondrial Disease and Anesthesia

It is increasingly common for children with mitochondrial disease to undergo surgery and anesthesia. Although many different anesthetics have been used successfully for these patients, serious, unexpected complications have occurred during and following anesthetic exposure. This has led to the wides...

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Main Authors: Vincent C. Hsieh MD, Elliot J. Krane MD, Philip G. Morgan MD
Format: Article
Language:English
Published: SciELO 2017-05-01
Series:Journal of Inborn Errors of Metabolism and Screening
Online Access:https://doi.org/10.1177/2326409817707770
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spelling doaj-578c1484aa0a4c4ba6356cafaf6660bb2020-11-25T01:48:51ZengSciELOJournal of Inborn Errors of Metabolism and Screening 2326-45942017-05-01510.1177/232640981770777010.1177_2326409817707770Mitochondrial Disease and AnesthesiaVincent C. Hsieh MD0Elliot J. Krane MD1Philip G. Morgan MD2 Department of Anesthesiology and Perioperative Medicine, University of Washington, Seattle, WA, USA Department of Pediatrics, Stanford University, Stanford, CA, USA Department of Anesthesiology and Perioperative Medicine, University of Washington, Seattle, WA, USAIt is increasingly common for children with mitochondrial disease to undergo surgery and anesthesia. Although many different anesthetics have been used successfully for these patients, serious, unexpected complications have occurred during and following anesthetic exposure. This has led to the widespread opinion among anesthesiologists that mitochondrial patients are at increased risk from the stress of surgery and anesthesia. Defects in function of the mitochondrial electron transport chain can lead to striking hypersensitivity to volatile anesthetics in children. Despite this striking finding, the connection between mitochondrial function and response to anesthetics is unknown. We review here the anesthetic considerations for patients with mitochondrial defects. In addition, we present an approach to anesthetic care of these patients at our institutions.https://doi.org/10.1177/2326409817707770
collection DOAJ
language English
format Article
sources DOAJ
author Vincent C. Hsieh MD
Elliot J. Krane MD
Philip G. Morgan MD
spellingShingle Vincent C. Hsieh MD
Elliot J. Krane MD
Philip G. Morgan MD
Mitochondrial Disease and Anesthesia
Journal of Inborn Errors of Metabolism and Screening
author_facet Vincent C. Hsieh MD
Elliot J. Krane MD
Philip G. Morgan MD
author_sort Vincent C. Hsieh MD
title Mitochondrial Disease and Anesthesia
title_short Mitochondrial Disease and Anesthesia
title_full Mitochondrial Disease and Anesthesia
title_fullStr Mitochondrial Disease and Anesthesia
title_full_unstemmed Mitochondrial Disease and Anesthesia
title_sort mitochondrial disease and anesthesia
publisher SciELO
series Journal of Inborn Errors of Metabolism and Screening
issn 2326-4594
publishDate 2017-05-01
description It is increasingly common for children with mitochondrial disease to undergo surgery and anesthesia. Although many different anesthetics have been used successfully for these patients, serious, unexpected complications have occurred during and following anesthetic exposure. This has led to the widespread opinion among anesthesiologists that mitochondrial patients are at increased risk from the stress of surgery and anesthesia. Defects in function of the mitochondrial electron transport chain can lead to striking hypersensitivity to volatile anesthetics in children. Despite this striking finding, the connection between mitochondrial function and response to anesthetics is unknown. We review here the anesthetic considerations for patients with mitochondrial defects. In addition, we present an approach to anesthetic care of these patients at our institutions.
url https://doi.org/10.1177/2326409817707770
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