EPA/DHA and vitamin A supplementation improves spatial memory and alleviates the age-related decrease in hippocampal RXRγ and kinase expression in rats

EPA/DHA and vitamin A supplementation improves spatial memory and alleviates the age-related decrease in hippocampal RXRγ and kinase expression in rats

Studies suggest that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and vitamin A are critical to delay aged-related cognitive decline. These nutrients regulate gene expression in the brain by binding to nuclear receptors such as the retinoid X receptors (RXRs) and the retinoic acid recepto...

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Bibliographic Details
Main Authors: Anne eLétondor, Benjamin eBuaud, Carole eVaysse, Emmanuel eRichard, Sophie eLaye, Véronique ePallet, Serge eAlfos
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Hippocampus
Vitamin A
spatial memory
kinases
Retinoid receptors
n-3 long-chain PUFA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00103/full

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