Long-Term Outcomes of T1 Colorectal Cancer after Endoscopic Resection
Background and Aims: Endoscopic resection (ER) for submucosal invasive colorectal cancer (T1 CRC) can be grouped as curative ER (C-ER) and non-curative ER (NC-ER). Little is known about the long-term outcomes of patients in these two groups. Therefore, we have evaluated the long-term outcomes in end...
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doaj-578ea5e19fdc4ec589dba43ca09f83022020-11-25T02:58:15ZengMDPI AGJournal of Clinical Medicine2077-03832020-07-0192451245110.3390/jcm9082451Long-Term Outcomes of T1 Colorectal Cancer after Endoscopic ResectionEun Young Park0Dong Hoon Baek1Moon Won Lee2Gwang Ha Kim3Do Youn Park4Geun Am Song5Department of Internal Medicine, Pusan National University School of Medicine, Busan 49421, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan 49421, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan 49421, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan 49421, KoreaBiomedical Research Institute, Pusan National University Hospital, Busan 49421, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan 49421, KoreaBackground and Aims: Endoscopic resection (ER) for submucosal invasive colorectal cancer (T1 CRC) can be grouped as curative ER (C-ER) and non-curative ER (NC-ER). Little is known about the long-term outcomes of patients in these two groups. Therefore, we have evaluated the long-term outcomes in endoscopically resected T1 CRC patients in C-ER and NC-ER groups. Methods: We conducted a retrospective study on 220 patients with T1 CRC treated with ER from January 2007 to December 2017. First, we investigated the long-term outcomes (5-year overall survival [OS] and recurrence-free survival [RFS]) in the C-ER group (<i>n</i> = 49). In the NC-ER group (<i>n</i> = 171), we compared long-term outcomes between patients who underwent additional surgical resection (ASR) (<i>n</i> = 117) and those who did not (surveillance-only, <i>n</i> = 54). Results: T1 CRC patients in the C-ER and NC-ER groups had a median follow-up of 44 (interquartile range 32–69) months. There was no risk of tumor recurrence and cancer-related deaths in patients with C-ER. In the NC-ER group, the 5-year OS rates were 75.3% and 92.6% in the surveillance-only and ASR subgroups, respectively. The hazard ratio (HR) for ASR in NC-ER vs. surveillance-only in NC-ER was statistically insignificant. However, RFS rates were significantly different between the ASR (97.2%) and surveillance-only (84.0%) subgroups. Multivariate analysis indicated a submucosal invasion depth (SID) of >2500 µm and margin positivity to be associated with recurrence. Conclusions: The surveillance-only approach can be considered as an alternative surgical option for T1 CRCs in selected patients undergoing NC-ER.https://www.mdpi.com/2077-0383/9/8/2451colorectal cancerendoscopic resectionoverall survivalrecurrence-free survival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eun Young Park Dong Hoon Baek Moon Won Lee Gwang Ha Kim Do Youn Park Geun Am Song |
spellingShingle |
Eun Young Park Dong Hoon Baek Moon Won Lee Gwang Ha Kim Do Youn Park Geun Am Song Long-Term Outcomes of T1 Colorectal Cancer after Endoscopic Resection Journal of Clinical Medicine colorectal cancer endoscopic resection overall survival recurrence-free survival |
author_facet |
Eun Young Park Dong Hoon Baek Moon Won Lee Gwang Ha Kim Do Youn Park Geun Am Song |
author_sort |
Eun Young Park |
title |
Long-Term Outcomes of T1 Colorectal Cancer after Endoscopic Resection |
title_short |
Long-Term Outcomes of T1 Colorectal Cancer after Endoscopic Resection |
title_full |
Long-Term Outcomes of T1 Colorectal Cancer after Endoscopic Resection |
title_fullStr |
Long-Term Outcomes of T1 Colorectal Cancer after Endoscopic Resection |
title_full_unstemmed |
Long-Term Outcomes of T1 Colorectal Cancer after Endoscopic Resection |
title_sort |
long-term outcomes of t1 colorectal cancer after endoscopic resection |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-07-01 |
description |
Background and Aims: Endoscopic resection (ER) for submucosal invasive colorectal cancer (T1 CRC) can be grouped as curative ER (C-ER) and non-curative ER (NC-ER). Little is known about the long-term outcomes of patients in these two groups. Therefore, we have evaluated the long-term outcomes in endoscopically resected T1 CRC patients in C-ER and NC-ER groups. Methods: We conducted a retrospective study on 220 patients with T1 CRC treated with ER from January 2007 to December 2017. First, we investigated the long-term outcomes (5-year overall survival [OS] and recurrence-free survival [RFS]) in the C-ER group (<i>n</i> = 49). In the NC-ER group (<i>n</i> = 171), we compared long-term outcomes between patients who underwent additional surgical resection (ASR) (<i>n</i> = 117) and those who did not (surveillance-only, <i>n</i> = 54). Results: T1 CRC patients in the C-ER and NC-ER groups had a median follow-up of 44 (interquartile range 32–69) months. There was no risk of tumor recurrence and cancer-related deaths in patients with C-ER. In the NC-ER group, the 5-year OS rates were 75.3% and 92.6% in the surveillance-only and ASR subgroups, respectively. The hazard ratio (HR) for ASR in NC-ER vs. surveillance-only in NC-ER was statistically insignificant. However, RFS rates were significantly different between the ASR (97.2%) and surveillance-only (84.0%) subgroups. Multivariate analysis indicated a submucosal invasion depth (SID) of >2500 µm and margin positivity to be associated with recurrence. Conclusions: The surveillance-only approach can be considered as an alternative surgical option for T1 CRCs in selected patients undergoing NC-ER. |
topic |
colorectal cancer endoscopic resection overall survival recurrence-free survival |
url |
https://www.mdpi.com/2077-0383/9/8/2451 |
work_keys_str_mv |
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