Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans.

Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans.

FK506 binding protein 51 (FKBP51) is an Hsp90 co-chaperone and regulator of the glucocorticoid receptor, and consequently of stress physiology. Clinical studies suggest a genetic link between FKBP51 and antidepressant response in mood disorders; however, the underlying mechanisms remain elusive. The...

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Bibliographic Details
Main Authors: Nils C Gassen, Jakob Hartmann, Jürgen Zschocke, Jens Stepan, Kathrin Hafner, Andreas Zellner, Thomas Kirmeier, Lorenz Kollmannsberger, Klaus V Wagner, Nina Dedic, Georgia Balsevich, Jan M Deussing, Stefan Kloiber, Susanne Lucae, Florian Holsboer, Matthias Eder, Manfred Uhr, Marcus Ising, Mathias V Schmidt, Theo Rein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-11-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC4227651?pdf=render

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