Graft modification of carboxymethyl chitosan with styrene and its biological applications
Abstract Background Carboxymethyl chitosan (CMCh) is a water-soluble chitosan derivative and it has been widely used in biomedical applications due to its unique properties. Modification of CMCh by graft copolymerization with different monomers is done in order to enhance its applications. Results G...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
SpringerOpen
2020-01-01
|
Series: | Beni-Suef University Journal of Basic and Applied Sciences |
Subjects: | |
Online Access: | https://doi.org/10.1186/s43088-019-0019-7 |
id |
doaj-579ba4bec78a499b8bad2f800ca9a816 |
---|---|
record_format |
Article |
spelling |
doaj-579ba4bec78a499b8bad2f800ca9a8162021-01-17T12:03:51ZengSpringerOpenBeni-Suef University Journal of Basic and Applied Sciences2314-85432020-01-019111510.1186/s43088-019-0019-7Graft modification of carboxymethyl chitosan with styrene and its biological applicationsOmayma F. Abdel Gawad0Department of Chemistry, Faculty of Science, Beni-Suef UniversityAbstract Background Carboxymethyl chitosan (CMCh) is a water-soluble chitosan derivative and it has been widely used in biomedical applications due to its unique properties. Modification of CMCh by graft copolymerization with different monomers is done in order to enhance its applications. Results Graft copolymerization of styrene (S) onto CMCh using ammonium persulfate (APS) as initiator was successfully done with optimization of grafting parameters. The new materials were prepared in nano size. The antibacterial activities against Streptococcus pneumonia (RCMB 010010), Staphylococcus aureus (RCMB 010028) as Gram-positive and Escherichia coli (RCMB 010052) as Gram-negative bacteria and antifungal activity against Aspergillus fumigates (RCMB 02568), Candida albicans (RCMB 05036), Syncephalastrum racemosum (RCMB 05922), and Geotricum candidum (RCMB 05097) were examined using the diffusion agar technique. Also, the cytotoxicity effect against mammalian cell lines (MCF-7cells (human breast cancer) and HTC-116 (colon carcinoma)) was evaluated. Conclusions The obtained data proved that grafted carboxymethyl chitosan with styrene (CMCh-g-S) shows better antimicrobial activities, while parent carboxymethyl chitosan showed higher activity than new grafted materials. Also the nano scaled grafted CMCh showed higher activities than grafted carboxymetyl chitosan in macro scale.https://doi.org/10.1186/s43088-019-0019-7Carboxymethyl chitosanGraftingAntimicrobial activityCytotoxicity evaluation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Omayma F. Abdel Gawad |
spellingShingle |
Omayma F. Abdel Gawad Graft modification of carboxymethyl chitosan with styrene and its biological applications Beni-Suef University Journal of Basic and Applied Sciences Carboxymethyl chitosan Grafting Antimicrobial activity Cytotoxicity evaluation |
author_facet |
Omayma F. Abdel Gawad |
author_sort |
Omayma F. Abdel Gawad |
title |
Graft modification of carboxymethyl chitosan with styrene and its biological applications |
title_short |
Graft modification of carboxymethyl chitosan with styrene and its biological applications |
title_full |
Graft modification of carboxymethyl chitosan with styrene and its biological applications |
title_fullStr |
Graft modification of carboxymethyl chitosan with styrene and its biological applications |
title_full_unstemmed |
Graft modification of carboxymethyl chitosan with styrene and its biological applications |
title_sort |
graft modification of carboxymethyl chitosan with styrene and its biological applications |
publisher |
SpringerOpen |
series |
Beni-Suef University Journal of Basic and Applied Sciences |
issn |
2314-8543 |
publishDate |
2020-01-01 |
description |
Abstract Background Carboxymethyl chitosan (CMCh) is a water-soluble chitosan derivative and it has been widely used in biomedical applications due to its unique properties. Modification of CMCh by graft copolymerization with different monomers is done in order to enhance its applications. Results Graft copolymerization of styrene (S) onto CMCh using ammonium persulfate (APS) as initiator was successfully done with optimization of grafting parameters. The new materials were prepared in nano size. The antibacterial activities against Streptococcus pneumonia (RCMB 010010), Staphylococcus aureus (RCMB 010028) as Gram-positive and Escherichia coli (RCMB 010052) as Gram-negative bacteria and antifungal activity against Aspergillus fumigates (RCMB 02568), Candida albicans (RCMB 05036), Syncephalastrum racemosum (RCMB 05922), and Geotricum candidum (RCMB 05097) were examined using the diffusion agar technique. Also, the cytotoxicity effect against mammalian cell lines (MCF-7cells (human breast cancer) and HTC-116 (colon carcinoma)) was evaluated. Conclusions The obtained data proved that grafted carboxymethyl chitosan with styrene (CMCh-g-S) shows better antimicrobial activities, while parent carboxymethyl chitosan showed higher activity than new grafted materials. Also the nano scaled grafted CMCh showed higher activities than grafted carboxymetyl chitosan in macro scale. |
topic |
Carboxymethyl chitosan Grafting Antimicrobial activity Cytotoxicity evaluation |
url |
https://doi.org/10.1186/s43088-019-0019-7 |
work_keys_str_mv |
AT omaymafabdelgawad graftmodificationofcarboxymethylchitosanwithstyreneanditsbiologicalapplications |
_version_ |
1724335481304383488 |