EMAST is a Form of Microsatellite Instability That is Initiated by Inflammation and Modulates Colorectal Cancer Progression

EMAST is a Form of Microsatellite Instability That is Initiated by Inflammation and Modulates Colorectal Cancer Progression

DNA mismatch repair (MMR) function is critical for correcting errors coincident with polymerase-driven DNA replication, and its proteins are frequent targets for inactivation (germline or somatic), generating a hypermutable tumor that drives cancer progression. The biomarker for defective DNA MMR is...

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Bibliographic Details
Main Authors: John M. Carethers, Minoru Koi, Stephanie S. Tseng-Rogenski
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Genes
Subjects:
DNA mismatch repair
microsatellite instability
genomic instability
colorectal cancer
MSH3
MutSβ
inflammation
short tandem repeats
EMAST
patient survival
patient outcome
Online Access:http://www.mdpi.com/2073-4425/6/2/185

Internet

http://www.mdpi.com/2073-4425/6/2/185

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