| Summary: | Objective: To study the effect of adjuvant Shuxuening injection therapy on the inflammatory
response mediated by TLRs in patients with acute exacerbation of COPD. Methods: Patients
with acute exacerbation of COPD who received Shuxuening injection combined with
conventional western medicine treatment in our hospital between May 2014 and December
2015 were selected for study, and before treatment as well as 1 week, 2 weeks, 3 weeks and 4
weeks after treatment, peripheral blood mononuclear cells were collected to determine TLRs
expression, and serum was collected to determine the levels of inflammatory cytokines and
airway remodeling molecules. Results: 1 week, 2 weeks, 3 weeks and 4 weeks after treatment,
TLR2 and TLR4 mRNA expression in peripheral blood mononuclear cells as well as TNF-
α, IL-6, MCP-1, VCAM-1, MMP2, MMP9, TGF-β and BMP-2 levels in serum of patients
with COPD were significantly lower than those before treatment, and TLR3, TLR7, TLR8 and
TLR9 mRNA expression were not significantly different from those before treatment; TLR2
and TLR4 mRNA expression in peripheral blood mononuclear cells were positively correlated
with serum TNF-α, IL-6, MCP-1, VCAM-1, MMP2, MMP9, TGF-β and BMP-2 levels.
Conclusion: Adjuvant Shuxuening injection therapy has significant inhibitory effect on the
inflammatory response mediated by TLRs in patients with acute exacerbation of COPD.
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