Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs
Cisplatin, carboplatin, and oxaliplatin are Pt-based drugs used in the chemotherapeutic eradication of cancer cells. Although most cancer patient cells initially respond well to the treatment, the clinical effectiveness declines over time as the cancer cells develop resistance to the drugs. The Pt-b...
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doaj-57a40653d04946cd91095fe7c66e89d22020-11-24T22:50:04ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-08-01198224910.3390/ijms19082249ijms19082249Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic DrugsIan Henry Lambert0Belinda Halling Sørensen1Department of Biology, Section of Cell Biology and Physiology, Universitetsparken 13, University of Copenhagen, 2100 Copenhagen, DenmarkDepartment of Biology, Section of Cell Biology and Physiology, Universitetsparken 13, University of Copenhagen, 2100 Copenhagen, DenmarkCisplatin, carboplatin, and oxaliplatin are Pt-based drugs used in the chemotherapeutic eradication of cancer cells. Although most cancer patient cells initially respond well to the treatment, the clinical effectiveness declines over time as the cancer cells develop resistance to the drugs. The Pt-based drugs are accumulated via membrane-bound transporters, translocated to the nucleus, where they trigger various intracellular cell death programs through DNA interaction. Here we illustrate how resistance to Pt-based drugs, acquired through limitation in the activity/subcellular localization of canonical drug transporters, might be circumvented by the facilitated uptake of Pt-based drug complexes via nanocarriers/endocytosis or lipophilic drugs by diffusion.http://www.mdpi.com/1422-0067/19/8/2249cisplatinB12 conjugatesPEG-HAS conjugatesfolate derivativesvolume-regulated anion channelsintegrins |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ian Henry Lambert Belinda Halling Sørensen |
spellingShingle |
Ian Henry Lambert Belinda Halling Sørensen Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs International Journal of Molecular Sciences cisplatin B12 conjugates PEG-HAS conjugates folate derivatives volume-regulated anion channels integrins |
author_facet |
Ian Henry Lambert Belinda Halling Sørensen |
author_sort |
Ian Henry Lambert |
title |
Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs |
title_short |
Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs |
title_full |
Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs |
title_fullStr |
Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs |
title_full_unstemmed |
Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs |
title_sort |
facilitating the cellular accumulation of pt-based chemotherapeutic drugs |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-08-01 |
description |
Cisplatin, carboplatin, and oxaliplatin are Pt-based drugs used in the chemotherapeutic eradication of cancer cells. Although most cancer patient cells initially respond well to the treatment, the clinical effectiveness declines over time as the cancer cells develop resistance to the drugs. The Pt-based drugs are accumulated via membrane-bound transporters, translocated to the nucleus, where they trigger various intracellular cell death programs through DNA interaction. Here we illustrate how resistance to Pt-based drugs, acquired through limitation in the activity/subcellular localization of canonical drug transporters, might be circumvented by the facilitated uptake of Pt-based drug complexes via nanocarriers/endocytosis or lipophilic drugs by diffusion. |
topic |
cisplatin B12 conjugates PEG-HAS conjugates folate derivatives volume-regulated anion channels integrins |
url |
http://www.mdpi.com/1422-0067/19/8/2249 |
work_keys_str_mv |
AT ianhenrylambert facilitatingthecellularaccumulationofptbasedchemotherapeuticdrugs AT belindahallingsørensen facilitatingthecellularaccumulationofptbasedchemotherapeuticdrugs |
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1725673508555456512 |