Functional Bowel Disorders Are Associated with a Central Immune Activation
Background. Subjects with depression and unexplained neurological symptoms have a high prevalence of gastrointestinal comorbidity probably related to the brain-gut communication. This study explored associations between functional gastrointestinal disorders (FGID) and inflammatory markers in subject...
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Series: | Gastroenterology Research and Practice |
Online Access: | http://dx.doi.org/10.1155/2017/1642912 |
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doaj-57b13f8cf3944f2697342ca4b6dfd7812020-11-25T00:36:56ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/16429121642912Functional Bowel Disorders Are Associated with a Central Immune ActivationPer G. Farup0Thor Ueland1Knut Rudi2Stian Lydersen3Knut Hestad4Department of Research, Innlandet Hospital Trust, 2381 Brumunddal, NorwayResearch Institute of Internal Medicine, Oslo University Hospital, Oslo, NorwayDepartment of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, P.O. Box 5003, 1432 Ås, NorwayRegional Centre for Child and Youth Mental Health and Child Welfare, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491 Trondheim, NorwayDepartment of Research, Innlandet Hospital Trust, 2381 Brumunddal, NorwayBackground. Subjects with depression and unexplained neurological symptoms have a high prevalence of gastrointestinal comorbidity probably related to the brain-gut communication. This study explored associations between functional gastrointestinal disorders (FGID) and inflammatory markers in subjects with these disorders. Methods. The FGID, including irritable bowel syndrome (IBS), were classified according to the Rome III criteria, and degree of symptoms was assessed with IBS symptom severity score (IBS-SSS). A range of interleukins (IL), chemokines and growth factors, tryptophan, and kynurenine were analysed in serum and the cerebrospinal fluid (CSF), and short-chain fatty acids (SCFA) were analysed in the faeces. The results are reported as partial correlation (pc) and p values. Results. Sixty-six subjects were included. IBS was associated with high levels of tryptophan (p=0.048) and kynurenine (p=0.019) and low level of IL-10 (p=0.047) in the CSF. IBS-SSS was associated with high tumor necrosis factor and low IL-10 in the CSF; pc=0.341 and p=0.009 and pc=−0.299 and p=0.023, respectively. Propionic minus butyric acid in faeces was negatively associated with IL-10 in the CSF (pc=−0.416, p=0.005). Conclusions. FGID were associated with a proinflammatory immune activation in the central nervous system and a disturbed tryptophan metabolism that could have been mediated by the faecal microbiota.http://dx.doi.org/10.1155/2017/1642912 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Per G. Farup Thor Ueland Knut Rudi Stian Lydersen Knut Hestad |
spellingShingle |
Per G. Farup Thor Ueland Knut Rudi Stian Lydersen Knut Hestad Functional Bowel Disorders Are Associated with a Central Immune Activation Gastroenterology Research and Practice |
author_facet |
Per G. Farup Thor Ueland Knut Rudi Stian Lydersen Knut Hestad |
author_sort |
Per G. Farup |
title |
Functional Bowel Disorders Are Associated with a Central Immune Activation |
title_short |
Functional Bowel Disorders Are Associated with a Central Immune Activation |
title_full |
Functional Bowel Disorders Are Associated with a Central Immune Activation |
title_fullStr |
Functional Bowel Disorders Are Associated with a Central Immune Activation |
title_full_unstemmed |
Functional Bowel Disorders Are Associated with a Central Immune Activation |
title_sort |
functional bowel disorders are associated with a central immune activation |
publisher |
Hindawi Limited |
series |
Gastroenterology Research and Practice |
issn |
1687-6121 1687-630X |
publishDate |
2017-01-01 |
description |
Background. Subjects with depression and unexplained neurological symptoms have a high prevalence of gastrointestinal comorbidity probably related to the brain-gut communication. This study explored associations between functional gastrointestinal disorders (FGID) and inflammatory markers in subjects with these disorders. Methods. The FGID, including irritable bowel syndrome (IBS), were classified according to the Rome III criteria, and degree of symptoms was assessed with IBS symptom severity score (IBS-SSS). A range of interleukins (IL), chemokines and growth factors, tryptophan, and kynurenine were analysed in serum and the cerebrospinal fluid (CSF), and short-chain fatty acids (SCFA) were analysed in the faeces. The results are reported as partial correlation (pc) and p values. Results. Sixty-six subjects were included. IBS was associated with high levels of tryptophan (p=0.048) and kynurenine (p=0.019) and low level of IL-10 (p=0.047) in the CSF. IBS-SSS was associated with high tumor necrosis factor and low IL-10 in the CSF; pc=0.341 and p=0.009 and pc=−0.299 and p=0.023, respectively. Propionic minus butyric acid in faeces was negatively associated with IL-10 in the CSF (pc=−0.416, p=0.005). Conclusions. FGID were associated with a proinflammatory immune activation in the central nervous system and a disturbed tryptophan metabolism that could have been mediated by the faecal microbiota. |
url |
http://dx.doi.org/10.1155/2017/1642912 |
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