New Application of 1,2,4-Triazole Derivatives as Antitubercular Agents. Structure, In Vitro Screening and Docking Studies

New Application of 1,2,4-Triazole Derivatives as Antitubercular Agents. Structure, In Vitro Screening and Docking Studies

A series of 1,2,4-triazole derivatives were synthesized and assigned as potential anti-tuberculosis substances. The molecular and crystal structures for the model compounds C1, C12, and C13 were determined using X-ray analysis. The X-ray investigation confirmed the synthesis pathway and the assumed...

Full description

Bibliographic Details
Main Authors:	Zbigniew Karczmarzyk, Marta Swatko-Ossor, Waldemar Wysocki, Monika Drozd, Grazyna Ginalska, Anna Pachuta-Stec, Monika Pitucha
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	Molecules
Subjects:	1,2,4-triazole structure X-ray analysis antitubercular agent molecular docking
Online Access:	https://www.mdpi.com/1420-3049/25/24/6033

Similar Items

Synthesis, In Vitro Screening and Docking Studies of New Thiosemicarbazide Derivatives as Antitubercular Agents
by: Monika Pitucha, et al.
Published: (2019-01-01)

Prediction of the Antiinflammatory Activity of New S-alkyl Derivatives of 1,2,4-triazol-3-thiones Using the PASS Computer Program and Molecular Docking
by: Natalya Mykolaivna Chalenko, et al.
Published: (2020-02-01)

Boulton-Katritzky Rearrangement of 5-Substituted Phenyl-3-[2-(morpholin-1-yl)ethyl]-1,2,4-oxadiazoles as a Synthetic Path to Spiropyrazoline Benzoates and Chloride with Antitubercular Properties
by: Lyudmila Kayukova, et al.
Published: (2021-02-01)

Design, Synthesis, in vitro Antiproliferative Activity, Binding Modeling of 1,2,4,-Triazoles as New Anti-Breast Cancer Agents
by: Murat Genc, et al.
Published: (2016-11-01)

Structural Insights and Docking Analysis of Adamantane-Linked 1,2,4-Triazole Derivatives as Potential 11β-HSD1 Inhibitors
by: Doaa A. Osman, et al.
Published: (2021-09-01)

Structure based approach for twin-enzyme targeted benzimidazolyl-1,2,4-triazole molecular hybrids as antifungal agents
by: Radha Ahuja, et al.
Published: (2020-06-01)

Synthesis of 1,6-bis(semicarbazide)hexanes and 1,6-bis(1,2,4-triazol-5-one)hexanes and their antiproliferative and antimicrobial activity
by: Pitucha M., et al.
Published: (2012-01-01)

Design, Synthesis, Antimicrobial Evaluation and Molecular Modeling Study of 1,2,4-Triazole-Based 4-Thiazolidinones
by: Sahar Ahmed, et al.
Published: (2016-04-01)

1,2,4-Triazoles as Important Antibacterial Agents
by: Małgorzata Strzelecka, et al.
Published: (2021-03-01)

Design, synthesis, in silico and in vitro antimicrobial screenings of novel 1,2,4-triazoles carrying 1,2,3-triazole scaffold with lipophilic side chain tether
by: Mohamed Reda Aouad, et al.
Published: (2017-11-01)

3-Benzyl-4-ethyl-1H-1,2,4-triazole-5(4H)-thione
by: Zbigniew Karczmarzyk, et al.
Published: (2013-02-01)

Synthesis and Biological Properties of Novel Triazole-Thiol and Thiadiazole Derivatives of the 1,2,4-Triazole-3(5)-one Class
by: Esra Düğdü, et al.
Published: (2014-02-01)

4-[(3,4-Dimethoxybenzylidene)amino]-5-(5-methyl-1-phenyl-1<em>H</em>-pyrazol-4-yl)-2,4-dihydro-3<em>H</em>-1,2,4-triazole-3-thione
by: Soukhyarani Gopal Nayak, et al.
Published: (2019-03-01)

New synthetic 1,2,4-triazole derivatives: Cholinesterase inhibition and molecular docking studies
by: Naheed Riaz, et al.
Published: (2020-01-01)

Preparation, Antimicrobial Activity and Docking Study of Vanadium Mixed Ligand Complexes Containing 4-Amino-5-hydrazinyl-4<i>H</i>-1,2,4-triazole-3-thiol and Aminophenol Derivatives
by: Doaa Domyati, et al.
Published: (2021-06-01)

An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine
by: Gildardo Rivera, et al.
Published: (2008-01-01)

Synthesis and antimicrobial activity of s-substituted derivatives of 1,2,4-triazol-3-thiol
by: Yevhen Karpun, et al.
Published: (2021-06-01)

Theoretical Study of Tautomeric Conformations for 1,2,4-Triazole Derivatives
by: Radia Mahboub
Published: (2021-03-01)

Thiazole–Chalcone Hybrids as Prospective Antitubercular and Antiproliferative Agents: Design, Synthesis, Biological, Molecular Docking Studies and In Silico ADME Evaluation
by: Ashok Babu Kasetti, et al.
Published: (2021-05-01)

Green ultrasound-assisted three-component click synthesis of novel 1H-1,2,3-triazole carrying benzothiazoles and fluorinated-1,2,4-triazole conjugates and their antimicrobial evaluation
by: Rezki Nadjet, et al.
Published: (2017-09-01)

Simple and Efficient Synthesis of Racemic 2-(tert-Butoxycarbon-ylamino)-2-methyl-3-(1H-1,2,4-triazol-1-yl)propanoic Acid, a New Derivative of β-(1,2,4-Triazol-1-yl)alanine
by: Abdelali Kerbal, et al.
Published: (2011-04-01)

Synthesis and in vitro study of some fused 1,2,4-triazole derivatives as antimycobacterial agents
by: Nareshvarma Seelam, et al.
Published: (2016-07-01)

Design, Synthesis, and Antimicrobial Activity of Certain New Indole-1,2,4 Triazole Conjugates
by: Reem I. Al-Wabli, et al.
Published: (2021-04-01)

3-Ethoxy-5-phenyl-1H-1,2,4-triazole
by: Ali M. Hebishy, et al.
Published: (2019-04-01)

Synthesis and Characterization of 1-(1-chlorocyclopropyl)-2-(1,2,4-triazol-1-yl)ethan-1-one
by: Ji Haifeng, et al.
Published: (2017-03-01)

Synthesis, molecular docking, and biological evaluation of Schiff base hybrids of 1,2,4-triazole-pyridine as dihydrofolate reductase inhibitors
by: D. Dewangan, et al.
Published: (2021-01-01)

Dataset on theoretical bio-evaluation of 1,2,4-thiadiazole-1,2,4-triazole analogues against epidermal growth factor receptor kinase down regulating human lung cancer
by: Abel Kolawole Oyebamiji, et al.
Published: (2021-08-01)

Highly Luminescent 4<i>H</i>-1,2,4-Triazole Derivatives: Synthesis, Molecular Structure and Photophysical Properties
by: Monika Olesiejuk, et al.
Published: (2020-12-01)

New S-alkylated 1,2,4-triazoles incorporating diphenyl sulfone moieties with potential antibacterial activity
by: Barbuceanu Stefania F., et al.
Published: (2009-01-01)

Determination of antimicrobial activity of some 1,2,4-triazole derivatives
by: M. S. M. Alrawashdeh
Published: (2018-04-01)

(E)-2-({[3-Benzylsulfanyl-5-(p-tolyl)-4H-1,2,4-triazol-4-yl]imino}methyl)phenol
by: Qian Hou, et al.
Published: (2017-02-01)

1,3-Bis(1,2,4-triazol-1-yl)adamantane
by: Roman Marchenko, et al.
Published: (2017-12-01)

Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents
by: Mukesh Kumari, et al.
Published: (2021-01-01)

Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents
by: Kakkar, S., et al.
Published: (2021)

Antibacterial Activity of Fluorobenzoylthiosemicarbazides and Their Cyclic Analogues with 1,2,4-Triazole Scaffold
by: Urszula Kosikowska, et al.
Published: (2021-12-01)

Synthesis, Molecular Docking and Anticancer Activity of Diflunisal Derivatives as Cyclooxygenase Enzyme Inhibitors
by: Göknil Pelin Coşkun, et al.
Published: (2018-08-01)

Triazole-Modified Peptidomimetics: An Opportunity for Drug Discovery and Development
by: Agnieszka Staśkiewicz, et al.
Published: (2021-05-01)

Synthèse de 1,2,4-triazoles trisubstitués en position 3, 4 et 5 comme ligands potentiels de RCPGs.
by: Bibian, Mathieu
Published: (2010)

Antitubercular compounds
by: TSAO, Shung Ling
Published: (1949)

Synthesis and Antifungal Activity of Novel Myrtenal-Based 4-Methyl-1,2,4-triazole-thioethers
by: Gui-Shan Lin, et al.
Published: (2017-01-01)

Cannot write session to /tmp/vufind_sessions/sess_8oqr5pq1uaaim7eba4chsincca