Cognitive deficits in people who have recovered from COVID-19
Background: There is growing concern about possible cognitive consequences of COVID-19, with reports of ‘Long COVID’ symptoms persisting into the chronic phase and case studies revealing neurological problems in severely affected patients. However, there is little information regarding the nature an...
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Elsevier
2021-09-01
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Series: | EClinicalMedicine |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537021003242 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Adam Hampshire William Trender Samuel R Chamberlain Amy E. Jolly Jon E. Grant Fiona Patrick Ndaba Mazibuko Steve CR Williams Joseph M Barnby Peter Hellyer Mitul A Mehta |
spellingShingle |
Adam Hampshire William Trender Samuel R Chamberlain Amy E. Jolly Jon E. Grant Fiona Patrick Ndaba Mazibuko Steve CR Williams Joseph M Barnby Peter Hellyer Mitul A Mehta Cognitive deficits in people who have recovered from COVID-19 EClinicalMedicine COVID-19 Long covid Cognition Deficits Online assessment Attention |
author_facet |
Adam Hampshire William Trender Samuel R Chamberlain Amy E. Jolly Jon E. Grant Fiona Patrick Ndaba Mazibuko Steve CR Williams Joseph M Barnby Peter Hellyer Mitul A Mehta |
author_sort |
Adam Hampshire |
title |
Cognitive deficits in people who have recovered from COVID-19 |
title_short |
Cognitive deficits in people who have recovered from COVID-19 |
title_full |
Cognitive deficits in people who have recovered from COVID-19 |
title_fullStr |
Cognitive deficits in people who have recovered from COVID-19 |
title_full_unstemmed |
Cognitive deficits in people who have recovered from COVID-19 |
title_sort |
cognitive deficits in people who have recovered from covid-19 |
publisher |
Elsevier |
series |
EClinicalMedicine |
issn |
2589-5370 |
publishDate |
2021-09-01 |
description |
Background: There is growing concern about possible cognitive consequences of COVID-19, with reports of ‘Long COVID’ symptoms persisting into the chronic phase and case studies revealing neurological problems in severely affected patients. However, there is little information regarding the nature and broader prevalence of cognitive problems post-infection or across the full spread of disease severity. Methods: We sought to confirm whether there was an association between cross-sectional cognitive performance data from 81,337 participants who between January and December 2020 undertook a clinically validated web-optimized assessment as part of the Great British Intelligence Test, and questionnaire items capturing self-report of suspected and confirmed COVID-19 infection and respiratory symptoms. Findings: People who had recovered from COVID-19, including those no longer reporting symptoms, exhibited significant cognitive deficits versus controls when controlling for age, gender, education level, income, racial-ethnic group, pre-existing medical disorders, tiredness, depression and anxiety. The deficits were of substantial effect size for people who had been hospitalised (N = 192), but also for non-hospitalised cases who had biological confirmation of COVID-19 infection (N = 326). Analysing markers of premorbid intelligence did not support these differences being present prior to infection. Finer grained analysis of performance across sub-tests supported the hypothesis that COVID-19 has a multi-domain impact on human cognition. Interpretation: Interpretation. These results accord with reports of ‘Long Covid’ cognitive symptoms that persist into the early-chronic phase. They should act as a clarion call for further research with longitudinal and neuroimaging cohorts to plot recovery trajectories and identify the biological basis of cognitive deficits in SARS-COV-2 survivors. Funding: Funding. AH is supported by the UK Dementia Research Institute Care Research and Technology Centre and Biomedical Research Centre at Imperial College London. WT is supported by the EPSRC Centre for Doctoral Training in Neurotechnology. SRC is funded by a Wellcome Trust Clinical Fellowship 110,049/Z/15/Z. JMB is supported by Medical Research Council (MR/N013700/1). MAM, SCRW and PJH are, in part, supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London |
topic |
COVID-19 Long covid Cognition Deficits Online assessment Attention |
url |
http://www.sciencedirect.com/science/article/pii/S2589537021003242 |
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doaj-57b44e83c05a49f19e74764fbb3ba4572021-09-25T05:10:49ZengElsevierEClinicalMedicine2589-53702021-09-0139101044Cognitive deficits in people who have recovered from COVID-19Adam Hampshire0William Trender1Samuel R Chamberlain2Amy E. Jolly3Jon E. Grant4Fiona Patrick5Ndaba Mazibuko6Steve CR Williams7Joseph M Barnby8Peter Hellyer9Mitul A Mehta10Department of Brain Sciences, Dementia Research Institute Care Research and Technology Centre, Imperial College London, 926, Sir Michael Uren Hub 86 Wood Lane, London, W12 0BZ; Corresponding author.Department of Brain Sciences, Dementia Research Institute Care Research and Technology Centre, Imperial College London, 926, Sir Michael Uren Hub 86 Wood Lane, London, W12 0BZDepartment of Psychiatry, University of Southampton, United Kingdom; Department of Psychiatry, University of Cambridge, United KingdomDepartment of Brain Sciences, Dementia Research Institute Care Research and Technology Centre, Imperial College London, 926, Sir Michael Uren Hub 86 Wood Lane, London, W12 0BZDepartment of Psychiatry, University of Chicago, United StatesInstitute of Psychiatry, Psychology and Neuroscience, King's College London, United KingdomInstitute of Psychiatry, Psychology and Neuroscience, King's College London, United KingdomInstitute of Psychiatry, Psychology and Neuroscience, King's College London, United KingdomInstitute of Psychiatry, Psychology and Neuroscience, King's College London, United KingdomDepartment of Brain Sciences, Dementia Research Institute Care Research and Technology Centre, Imperial College London, 926, Sir Michael Uren Hub 86 Wood Lane, London, W12 0BZ; Institute of Psychiatry, Psychology and Neuroscience, King's College London, United KingdomInstitute of Psychiatry, Psychology and Neuroscience, King's College London, United KingdomBackground: There is growing concern about possible cognitive consequences of COVID-19, with reports of ‘Long COVID’ symptoms persisting into the chronic phase and case studies revealing neurological problems in severely affected patients. However, there is little information regarding the nature and broader prevalence of cognitive problems post-infection or across the full spread of disease severity. Methods: We sought to confirm whether there was an association between cross-sectional cognitive performance data from 81,337 participants who between January and December 2020 undertook a clinically validated web-optimized assessment as part of the Great British Intelligence Test, and questionnaire items capturing self-report of suspected and confirmed COVID-19 infection and respiratory symptoms. Findings: People who had recovered from COVID-19, including those no longer reporting symptoms, exhibited significant cognitive deficits versus controls when controlling for age, gender, education level, income, racial-ethnic group, pre-existing medical disorders, tiredness, depression and anxiety. The deficits were of substantial effect size for people who had been hospitalised (N = 192), but also for non-hospitalised cases who had biological confirmation of COVID-19 infection (N = 326). Analysing markers of premorbid intelligence did not support these differences being present prior to infection. Finer grained analysis of performance across sub-tests supported the hypothesis that COVID-19 has a multi-domain impact on human cognition. Interpretation: Interpretation. These results accord with reports of ‘Long Covid’ cognitive symptoms that persist into the early-chronic phase. They should act as a clarion call for further research with longitudinal and neuroimaging cohorts to plot recovery trajectories and identify the biological basis of cognitive deficits in SARS-COV-2 survivors. Funding: Funding. AH is supported by the UK Dementia Research Institute Care Research and Technology Centre and Biomedical Research Centre at Imperial College London. WT is supported by the EPSRC Centre for Doctoral Training in Neurotechnology. SRC is funded by a Wellcome Trust Clinical Fellowship 110,049/Z/15/Z. JMB is supported by Medical Research Council (MR/N013700/1). MAM, SCRW and PJH are, in part, supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College Londonhttp://www.sciencedirect.com/science/article/pii/S2589537021003242COVID-19Long covidCognitionDeficitsOnline assessmentAttention |