FIRST LINE 5-FU-BASED CHEMOTHERAPY WITH/WITHOUT BEVACIZUMAB FOR METASTATIC COLORECTAL CANCER: TISSUE BIOMARKER CANDIDATES
Purpose: Colorectal cancer is the second leading cause of cancer mortality in the USA. According to Bulgarian National Statistics Institute, 2370 colon and 1664 rectal cancer cases were diagnosed in 2012 with total number of patients 29995. Adding bevacizumab to chemotherapy in patients with metasta...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Peytchinski Publishing
2016-03-01
|
Series: | Journal of IMAB |
Subjects: | |
Online Access: | http://www.journal-imab-bg.org/issues-2016/issue1/JofIMAB_2016-22-1p1039-1044.pdf |
id |
doaj-57b496b9812b48e6bf14ae06094094b6 |
---|---|
record_format |
Article |
spelling |
doaj-57b496b9812b48e6bf14ae06094094b62020-11-25T01:11:36ZengPeytchinski PublishingJournal of IMAB1312-773X2016-03-012211039104410.5272/jimab.2016221.1039FIRST LINE 5-FU-BASED CHEMOTHERAPY WITH/WITHOUT BEVACIZUMAB FOR METASTATIC COLORECTAL CANCER: TISSUE BIOMARKER CANDIDATESAssia Konsoulova0Ivan Donev1Nikolay Conev2Sonya Draganova3Nadezhda Petrova4Eleonora Dimitrova5Hristo Popov6Kameliya Bratoeva7Petar Ghenev8Medical Oncology Clinic, University Hospital “St. Marina”- VarnaMedical Oncology Clinic, University Hospital “St. Marina”- VarnaMedical Oncology Clinic, University Hospital “St. Marina”- VarnaMedical Oncology Clinic, University Hospital “St. Marina”- VarnaGeneral and specialized pathology Clinic, University Hospital “St. Marina”- VarnaMedical Oncology Clinic, University Hospital “St. Marina”- VarnaGeneral and specialized pathology Clinic, University Hospital “St. Marina”- VarnaDivision of pathophysiology, Department of Physiology and pathophysiology, Medical University, Varna, Bulgaria.General and specialized pathology Clinic, University Hospital “St. Marina”- VarnaPurpose: Colorectal cancer is the second leading cause of cancer mortality in the USA. According to Bulgarian National Statistics Institute, 2370 colon and 1664 rectal cancer cases were diagnosed in 2012 with total number of patients 29995. Adding bevacizumab to chemotherapy in patients with metastatic disease improves progression-free survival (PFS) but no predictive markers have been proven in the clinical practice. In our study we examined two tissue biomarkers that may correlate with response to bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer. Patients and Methods: 54 patients with metastatic colorectal cancer were assigned to first line 5-Fu-based chemotherapy with/without bevacizumab. The primary end point was PFS, with additional determination of response and toxicity. Paraffin-embedded samples from primary tumors were collected from all 54 patients. Expression levels of two tumor biomarkers VEGFR-2 and Neuropilin 1 (NP-1) were evaluated with immunohistochemistry. Results: The median PFS for the group treated with CT/Bev was 8.8 months, compared with 5.4 months for the group with chemotherapy alone (95% CI, log-rank test P =0.003). The corresponding overall response rates were 19.3% and 10.2% respectively (P < 0.05 for CT/Bev vs CT). Patients with low NP-1 had statistically significant prolongation of PFS as compared to those with high NP-1 (95% CI, log rank test p= 0.017). Patients with low NP-1 appeared to experience a larger bevacizumab treatment effect in terms of PFS (p=0,049,HR 0.333, 95% CI, 0.111 to 0.995) than patients with high NP-1. Conclusion: The addition of bevacizumab to 5-Fu based chemotherapy improves PFS for patients with metastatic colorectal cancer. Expression of tumor NP-1 is a potential biomarker candidate for prediction of clinical outcome in patients with metastatic colorectal cancer, treated with first line chemotherapy plus bevacizumab.http://www.journal-imab-bg.org/issues-2016/issue1/JofIMAB_2016-22-1p1039-1044.pdfcolorectalbevacizumabVEGFR-2biomarkersneuropillin-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Assia Konsoulova Ivan Donev Nikolay Conev Sonya Draganova Nadezhda Petrova Eleonora Dimitrova Hristo Popov Kameliya Bratoeva Petar Ghenev |
spellingShingle |
Assia Konsoulova Ivan Donev Nikolay Conev Sonya Draganova Nadezhda Petrova Eleonora Dimitrova Hristo Popov Kameliya Bratoeva Petar Ghenev FIRST LINE 5-FU-BASED CHEMOTHERAPY WITH/WITHOUT BEVACIZUMAB FOR METASTATIC COLORECTAL CANCER: TISSUE BIOMARKER CANDIDATES Journal of IMAB colorectal bevacizumab VEGFR-2 biomarkers neuropillin-1 |
author_facet |
Assia Konsoulova Ivan Donev Nikolay Conev Sonya Draganova Nadezhda Petrova Eleonora Dimitrova Hristo Popov Kameliya Bratoeva Petar Ghenev |
author_sort |
Assia Konsoulova |
title |
FIRST LINE 5-FU-BASED CHEMOTHERAPY WITH/WITHOUT BEVACIZUMAB FOR METASTATIC COLORECTAL CANCER: TISSUE BIOMARKER CANDIDATES |
title_short |
FIRST LINE 5-FU-BASED CHEMOTHERAPY WITH/WITHOUT BEVACIZUMAB FOR METASTATIC COLORECTAL CANCER: TISSUE BIOMARKER CANDIDATES |
title_full |
FIRST LINE 5-FU-BASED CHEMOTHERAPY WITH/WITHOUT BEVACIZUMAB FOR METASTATIC COLORECTAL CANCER: TISSUE BIOMARKER CANDIDATES |
title_fullStr |
FIRST LINE 5-FU-BASED CHEMOTHERAPY WITH/WITHOUT BEVACIZUMAB FOR METASTATIC COLORECTAL CANCER: TISSUE BIOMARKER CANDIDATES |
title_full_unstemmed |
FIRST LINE 5-FU-BASED CHEMOTHERAPY WITH/WITHOUT BEVACIZUMAB FOR METASTATIC COLORECTAL CANCER: TISSUE BIOMARKER CANDIDATES |
title_sort |
first line 5-fu-based chemotherapy with/without bevacizumab for metastatic colorectal cancer: tissue biomarker candidates |
publisher |
Peytchinski Publishing |
series |
Journal of IMAB |
issn |
1312-773X |
publishDate |
2016-03-01 |
description |
Purpose: Colorectal cancer is the second leading cause of cancer mortality in the USA. According to Bulgarian National Statistics Institute, 2370 colon and 1664 rectal cancer cases were diagnosed in 2012 with total number of patients 29995. Adding bevacizumab to chemotherapy in patients with metastatic disease improves progression-free survival (PFS) but no predictive markers have been proven in the clinical practice. In our study we examined two tissue biomarkers that may correlate with response to bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer.
Patients and Methods: 54 patients with metastatic colorectal cancer were assigned to first line 5-Fu-based chemotherapy with/without bevacizumab. The primary end point was PFS, with additional determination of response and toxicity. Paraffin-embedded samples from primary tumors were collected from all 54 patients. Expression levels of two tumor biomarkers VEGFR-2 and Neuropilin 1 (NP-1) were evaluated with immunohistochemistry.
Results: The median PFS for the group treated with CT/Bev was 8.8 months, compared with 5.4 months for the group with chemotherapy alone (95% CI, log-rank test P =0.003). The corresponding overall response rates were 19.3% and 10.2% respectively (P < 0.05 for CT/Bev vs CT). Patients with low NP-1 had statistically significant prolongation of PFS as compared to those with high NP-1 (95% CI, log rank test p= 0.017). Patients with low NP-1 appeared to experience a larger bevacizumab treatment effect in terms of PFS (p=0,049,HR 0.333, 95% CI, 0.111 to 0.995) than patients with high NP-1.
Conclusion: The addition of bevacizumab to 5-Fu based chemotherapy improves PFS for patients with metastatic colorectal cancer. Expression of tumor NP-1 is a potential biomarker candidate for prediction of clinical outcome in patients with metastatic colorectal cancer, treated with first line chemotherapy plus bevacizumab. |
topic |
colorectal bevacizumab VEGFR-2 biomarkers neuropillin-1 |
url |
http://www.journal-imab-bg.org/issues-2016/issue1/JofIMAB_2016-22-1p1039-1044.pdf |
work_keys_str_mv |
AT assiakonsoulova firstline5fubasedchemotherapywithwithoutbevacizumabformetastaticcolorectalcancertissuebiomarkercandidates AT ivandonev firstline5fubasedchemotherapywithwithoutbevacizumabformetastaticcolorectalcancertissuebiomarkercandidates AT nikolayconev firstline5fubasedchemotherapywithwithoutbevacizumabformetastaticcolorectalcancertissuebiomarkercandidates AT sonyadraganova firstline5fubasedchemotherapywithwithoutbevacizumabformetastaticcolorectalcancertissuebiomarkercandidates AT nadezhdapetrova firstline5fubasedchemotherapywithwithoutbevacizumabformetastaticcolorectalcancertissuebiomarkercandidates AT eleonoradimitrova firstline5fubasedchemotherapywithwithoutbevacizumabformetastaticcolorectalcancertissuebiomarkercandidates AT hristopopov firstline5fubasedchemotherapywithwithoutbevacizumabformetastaticcolorectalcancertissuebiomarkercandidates AT kameliyabratoeva firstline5fubasedchemotherapywithwithoutbevacizumabformetastaticcolorectalcancertissuebiomarkercandidates AT petarghenev firstline5fubasedchemotherapywithwithoutbevacizumabformetastaticcolorectalcancertissuebiomarkercandidates |
_version_ |
1725170672423927808 |