Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study
African American women are affected by earlier onset of age-associated health deteriorations and obesity disproportionally, but little is known about the mechanism linking body mass index (BMI) and biological aging among this population. DNA methylation age acceleration (DNAm AA), measuring the diff...
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doaj-57b834ee48a44cae97be2dd3f3adad822020-11-25T01:35:11ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-08-012017427310.3390/ijms20174273ijms20174273Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN StudyChengchen Li0Zeyuan Wang1Theresa Hardy2Yunfeng Huang3Qin Hui4Cindy A. Crusto5Michelle L. Wright6Jacquelyn Y. Taylor7Yan V. Sun8Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Road NE, Atlanta, GA 30322, USADepartment of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Road NE, Atlanta, GA 30322, USANew York University Rory Meyers College of Nursing, 433 First Avenue, New York, NY 10010, USADepartment of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Road NE, Atlanta, GA 30322, USADepartment of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Road NE, Atlanta, GA 30322, USADepartment of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USASchool of Nursing, University of Texas at Austin, 1710 Red River Street, Austin, TX 78712, USANew York University Rory Meyers College of Nursing, 433 First Avenue, New York, NY 10010, USADepartment of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Road NE, Atlanta, GA 30322, USAAfrican American women are affected by earlier onset of age-associated health deteriorations and obesity disproportionally, but little is known about the mechanism linking body mass index (BMI) and biological aging among this population. DNA methylation age acceleration (DNAm AA), measuring the difference between DNA methylation age and chronological age, is a novel biomarker of the biological aging process, and predicts aging-related disease outcomes. The present study estimated cross-tissue DNA methylation age acceleration using saliva samples from 232 African American mothers. Cross-sectional regression analyses were performed to assess the association of BMI with DNAm AA. The average chronological age and DNA methylation age were 31.67 years, and 28.79 years, respectively. After adjusting for smoking, hypertension diagnosis history, and socioeconomic factors (education, marital status, household income), a 1 kg/m<sup>2</sup> increase in BMI is associated with 0.14 years increment of DNAm AA (95% CI: (0.08, 0.21)). The conclusion: in African American women, high BMI is independently associated with saliva-based DNA methylation age acceleration, after adjusting for smoking, hypertension, and socioeconomic status. This finding supports that high BMI accelerates biological aging, and plays a key role in age-related disease outcomes among African American women.https://www.mdpi.com/1422-0067/20/17/4273DNA methylation age accelerationagingobesityBMIAfrican American |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chengchen Li Zeyuan Wang Theresa Hardy Yunfeng Huang Qin Hui Cindy A. Crusto Michelle L. Wright Jacquelyn Y. Taylor Yan V. Sun |
spellingShingle |
Chengchen Li Zeyuan Wang Theresa Hardy Yunfeng Huang Qin Hui Cindy A. Crusto Michelle L. Wright Jacquelyn Y. Taylor Yan V. Sun Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study International Journal of Molecular Sciences DNA methylation age acceleration aging obesity BMI African American |
author_facet |
Chengchen Li Zeyuan Wang Theresa Hardy Yunfeng Huang Qin Hui Cindy A. Crusto Michelle L. Wright Jacquelyn Y. Taylor Yan V. Sun |
author_sort |
Chengchen Li |
title |
Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study |
title_short |
Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study |
title_full |
Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study |
title_fullStr |
Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study |
title_full_unstemmed |
Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study |
title_sort |
association of obesity with dna methylation age acceleration in african american mothers from the intergen study |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-08-01 |
description |
African American women are affected by earlier onset of age-associated health deteriorations and obesity disproportionally, but little is known about the mechanism linking body mass index (BMI) and biological aging among this population. DNA methylation age acceleration (DNAm AA), measuring the difference between DNA methylation age and chronological age, is a novel biomarker of the biological aging process, and predicts aging-related disease outcomes. The present study estimated cross-tissue DNA methylation age acceleration using saliva samples from 232 African American mothers. Cross-sectional regression analyses were performed to assess the association of BMI with DNAm AA. The average chronological age and DNA methylation age were 31.67 years, and 28.79 years, respectively. After adjusting for smoking, hypertension diagnosis history, and socioeconomic factors (education, marital status, household income), a 1 kg/m<sup>2</sup> increase in BMI is associated with 0.14 years increment of DNAm AA (95% CI: (0.08, 0.21)). The conclusion: in African American women, high BMI is independently associated with saliva-based DNA methylation age acceleration, after adjusting for smoking, hypertension, and socioeconomic status. This finding supports that high BMI accelerates biological aging, and plays a key role in age-related disease outcomes among African American women. |
topic |
DNA methylation age acceleration aging obesity BMI African American |
url |
https://www.mdpi.com/1422-0067/20/17/4273 |
work_keys_str_mv |
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