Cryoglobulin induced skin ulceration

• Main Author: Fatima Razvi
• Format: Article
• Language: English
• Published: Deccan College of Medical Sciences 2015-01-01
• Series: Journal of Medical and Allied Sciences
• Subjects: SLE; skin ulcers; cryoglobulins
• Online Access: http://jmas.in/Vol5Issue1/Cryoglobulin%20induced%20skin%20ulceration.pdf

Lupus Erythematosus (LE) is a multi-organ auto-immune disease which results from complex interaction of genetic and environmental factors. The clinical spectrum ranges from minor cutaneous lesions to life threatening multi-organ dysfunction. The skin manifestations are variable and common and range from LE specific to LE non-specific cutaneous disease. Vasculitis is one of the most common non-specific skin lesion of Systemic lupus erythematosus (SLE) and appears as purpuric lesions, infarcts along lateral nail folds, peripheral gangrene, sub-cutaneous nodules and ulcers. Mixed cryoglobulinaemia (type II) is associated with connective tissue disorders including SLE. Skin manifestations are seen in 60-100% patients and are more common in females. The most common manifestation is palpable purpura of lower extremities seen in 30-100% which often is triggered in winter or on cold exposure. Skin infarction, hemorrhagic crusts and ulcers are seen in 25% of patients. Wide spread necrotic ulcers are seen in 10-25% of patients which are often exacerbated by cold.