Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration

• Main Authors: Zimo Zhou, Mohammad Showkat Hossain, Da Liu
• Format: Article
• Language: English
• Published: BMC 2021-01-01
• Series: Stem Cell Research & Therapy
• Subjects: Long noncoding RNA; H19; Osteogenic differentiation; Bone regeneration
• Online Access: https://doi.org/10.1186/s13287-021-02149-4

Abstract Osteogenic differentiation and bone regeneration are complex processes involving multiple genes and multiple steps. In this review, we summarize the effects of the long noncoding RNA (lncRNA) H19 on osteogenic differentiation. Osteogenic differentiation includes matrix secretion and calcium mineralization as hallmarks of osteoblast differentiation and the absorption of calcium and phosphorus as hallmarks of osteoclast differentiation. Mesenchymal stem cells (MSCs) form osteoprogenitor cells, pre-osteoblasts, mature osteoblasts, and osteocytes through induction and differentiation. lncRNAs regulate the expression of coding genes and play essential roles in osteogenic differentiation and bone regeneration. The lncRNA H19 is known to have vital roles in osteogenic induction. This review highlights the role of H19 as a novel target for osteogenic differentiation and the promotion of bone regeneration.