Xanthones Content in Swertia multicaulis D. Don from Nepal
The medicinal plant Swertia multicaulis D. Don was collected in Rasuwa District (Nepal) and the xanthone content of its ethyl acetate extracts was studied. The total amount of xanthones in S. multicaulis determined by HPLC reaches almost 13 g of xanthones per 1 kg of dry matter. The identification o...
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doaj-57ccb6cec18042c187dd43ac818a36062020-11-24T20:48:22ZengMDPI AGMolecules1420-30492018-05-01235106710.3390/molecules23051067molecules23051067Xanthones Content in Swertia multicaulis D. Don from NepalBinu Timsina0Pavel Kindlmann1Maan B. Rokaya2Naděžda Vrchotová3Jan Tříska4Štěpán Horník5Jan Sýkora6Institute for Environmental Studies, Faculty of Science, Charles University, Benátská 2, 128 01 Prague, Czech RepublicInstitute for Environmental Studies, Faculty of Science, Charles University, Benátská 2, 128 01 Prague, Czech RepublicDepartment of Biodiversity Research, Global Change Research Institute, Czech Academy of Sciences, Bělidla 986/4a, 603 00 Brno, Czech RepublicLaboratory of Metabolomics and Isotopic Analyses, Global Change Research Institute, Czech Academy of Sciences, Bělidla 986/4a, 603 00 Brno, Czech RepublicLaboratory of Metabolomics and Isotopic Analyses, Global Change Research Institute, Czech Academy of Sciences, Bělidla 986/4a, 603 00 Brno, Czech RepublicInstitute of Chemical Process Fundamentals, Czech Academy of Sciences, Rozvojová 135, 165 02 Prague, Czech RepublicInstitute of Chemical Process Fundamentals, Czech Academy of Sciences, Rozvojová 135, 165 02 Prague, Czech RepublicThe medicinal plant Swertia multicaulis D. Don was collected in Rasuwa District (Nepal) and the xanthone content of its ethyl acetate extracts was studied. The total amount of xanthones in S. multicaulis determined by HPLC reaches almost 13 g of xanthones per 1 kg of dry matter. The identification of xanthones in S. multicaulis was achieved by a combination of HPLC, LC–MS and LC–NMR. The final assignment of the individual chemical structures was provided by NMR, supported by preparative HPLC. In eight chromatographic peaks, four major xanthones were identified—1,3-dihydroxy-5,8-dimethoxyxanthone, 1-hydroxy-3,5,8-trimethoxyxanthone, bellidifolin (1,5,8-tri-hydroxy-3-methoxyxanthone), and decussatin (1-hydroxy-3,7,8-trimethoxyxanthone).http://www.mdpi.com/1420-3049/23/5/1067SwertiaGentianaceaeHPLCLC–MSNMRphytochemistrysecondary metabolites |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Binu Timsina Pavel Kindlmann Maan B. Rokaya Naděžda Vrchotová Jan Tříska Štěpán Horník Jan Sýkora |
spellingShingle |
Binu Timsina Pavel Kindlmann Maan B. Rokaya Naděžda Vrchotová Jan Tříska Štěpán Horník Jan Sýkora Xanthones Content in Swertia multicaulis D. Don from Nepal Molecules Swertia Gentianaceae HPLC LC–MS NMR phytochemistry secondary metabolites |
author_facet |
Binu Timsina Pavel Kindlmann Maan B. Rokaya Naděžda Vrchotová Jan Tříska Štěpán Horník Jan Sýkora |
author_sort |
Binu Timsina |
title |
Xanthones Content in Swertia multicaulis D. Don from Nepal |
title_short |
Xanthones Content in Swertia multicaulis D. Don from Nepal |
title_full |
Xanthones Content in Swertia multicaulis D. Don from Nepal |
title_fullStr |
Xanthones Content in Swertia multicaulis D. Don from Nepal |
title_full_unstemmed |
Xanthones Content in Swertia multicaulis D. Don from Nepal |
title_sort |
xanthones content in swertia multicaulis d. don from nepal |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2018-05-01 |
description |
The medicinal plant Swertia multicaulis D. Don was collected in Rasuwa District (Nepal) and the xanthone content of its ethyl acetate extracts was studied. The total amount of xanthones in S. multicaulis determined by HPLC reaches almost 13 g of xanthones per 1 kg of dry matter. The identification of xanthones in S. multicaulis was achieved by a combination of HPLC, LC–MS and LC–NMR. The final assignment of the individual chemical structures was provided by NMR, supported by preparative HPLC. In eight chromatographic peaks, four major xanthones were identified—1,3-dihydroxy-5,8-dimethoxyxanthone, 1-hydroxy-3,5,8-trimethoxyxanthone, bellidifolin (1,5,8-tri-hydroxy-3-methoxyxanthone), and decussatin (1-hydroxy-3,7,8-trimethoxyxanthone). |
topic |
Swertia Gentianaceae HPLC LC–MS NMR phytochemistry secondary metabolites |
url |
http://www.mdpi.com/1420-3049/23/5/1067 |
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