The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes
Abstract H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes-related mortality, and cardiovascular...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-04-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-88352-y |
id |
doaj-57d0b777d8664b92b1ec1e3d5dbadfde |
---|---|
record_format |
Article |
spelling |
doaj-57d0b777d8664b92b1ec1e3d5dbadfde2021-05-02T11:31:57ZengNature Publishing GroupScientific Reports2045-23222021-04-011111910.1038/s41598-021-88352-yThe pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetesJakob Appel Østergaard0Fanny Jansson Sigfrids1Carol Forsblom2Emma H. Dahlström3Lena M. Thorn4Valma Harjutsalo5Allan Flyvbjerg6Steffen Thiel7Troels Krarup Hansen8Per-Henrik Groop9Department of Endocrinology and Internal Medicine, Aarhus University HospitalFolkhälsan Institute of Genetics, Folkhälsan Research CenterFolkhälsan Institute of Genetics, Folkhälsan Research CenterFolkhälsan Institute of Genetics, Folkhälsan Research CenterFolkhälsan Institute of Genetics, Folkhälsan Research CenterFolkhälsan Institute of Genetics, Folkhälsan Research CenterSteno Diabetes Center Copenhagen, The Capital Region of DenmarkDepartment of Biomedicine, Aarhus UniversitySteno Diabetes Center Aarhus, Aarhus University HospitalFolkhälsan Institute of Genetics, Folkhälsan Research CenterAbstract H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes-related mortality, and cardiovascular events. Event rates per 10-unit H-ficolin-increase were compared in an observational follow-up of 2,410 individuals with type 1 diabetes from the FinnDiane Study. DKD progression occurred in 400 individuals. The unadjusted hazard ratio (HR) for progression was 1.29 (1.18–1.40) and 1.16 (1.05–1.29) after adjustment for diabetes duration, sex, HbA1c, systolic blood pressure, and smoking status. After adding triglycerides to the model, the HR decreased to 1.07 (0.97–1.18). In all, 486 individuals died, including 268 deaths of cardiovascular causes and 192 deaths of complications to diabetes. HRs for all-cause mortality and cardiovascular mortality were 1.13 (1.04–1.22) and 1.05 (0.93–1.17), respectively, in unadjusted analyses. These estimates lost statistical significance in adjusted models. However, the unadjusted HR for diabetes-related mortality was 1.19 (1.05–1.35) and 1.18 (1.02–1.37) with the most stringent adjustment level. Our results, therefore, indicate that H-ficolin predicts diabetes-related mortality, but neither all-cause mortality nor fatal/non-fatal cardiovascular events. Furthermore, H-ficolin is associated with DKD progression, however, not independently of the fully adjusted model.https://doi.org/10.1038/s41598-021-88352-y |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jakob Appel Østergaard Fanny Jansson Sigfrids Carol Forsblom Emma H. Dahlström Lena M. Thorn Valma Harjutsalo Allan Flyvbjerg Steffen Thiel Troels Krarup Hansen Per-Henrik Groop |
spellingShingle |
Jakob Appel Østergaard Fanny Jansson Sigfrids Carol Forsblom Emma H. Dahlström Lena M. Thorn Valma Harjutsalo Allan Flyvbjerg Steffen Thiel Troels Krarup Hansen Per-Henrik Groop The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes Scientific Reports |
author_facet |
Jakob Appel Østergaard Fanny Jansson Sigfrids Carol Forsblom Emma H. Dahlström Lena M. Thorn Valma Harjutsalo Allan Flyvbjerg Steffen Thiel Troels Krarup Hansen Per-Henrik Groop |
author_sort |
Jakob Appel Østergaard |
title |
The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes |
title_short |
The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes |
title_full |
The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes |
title_fullStr |
The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes |
title_full_unstemmed |
The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes |
title_sort |
pattern-recognition molecule h-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-04-01 |
description |
Abstract H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes-related mortality, and cardiovascular events. Event rates per 10-unit H-ficolin-increase were compared in an observational follow-up of 2,410 individuals with type 1 diabetes from the FinnDiane Study. DKD progression occurred in 400 individuals. The unadjusted hazard ratio (HR) for progression was 1.29 (1.18–1.40) and 1.16 (1.05–1.29) after adjustment for diabetes duration, sex, HbA1c, systolic blood pressure, and smoking status. After adding triglycerides to the model, the HR decreased to 1.07 (0.97–1.18). In all, 486 individuals died, including 268 deaths of cardiovascular causes and 192 deaths of complications to diabetes. HRs for all-cause mortality and cardiovascular mortality were 1.13 (1.04–1.22) and 1.05 (0.93–1.17), respectively, in unadjusted analyses. These estimates lost statistical significance in adjusted models. However, the unadjusted HR for diabetes-related mortality was 1.19 (1.05–1.35) and 1.18 (1.02–1.37) with the most stringent adjustment level. Our results, therefore, indicate that H-ficolin predicts diabetes-related mortality, but neither all-cause mortality nor fatal/non-fatal cardiovascular events. Furthermore, H-ficolin is associated with DKD progression, however, not independently of the fully adjusted model. |
url |
https://doi.org/10.1038/s41598-021-88352-y |
work_keys_str_mv |
AT jakobappeløstergaard thepatternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT fannyjanssonsigfrids thepatternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT carolforsblom thepatternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT emmahdahlstrom thepatternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT lenamthorn thepatternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT valmaharjutsalo thepatternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT allanflyvbjerg thepatternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT steffenthiel thepatternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT troelskraruphansen thepatternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT perhenrikgroop thepatternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT jakobappeløstergaard patternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT fannyjanssonsigfrids patternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT carolforsblom patternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT emmahdahlstrom patternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT lenamthorn patternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT valmaharjutsalo patternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT allanflyvbjerg patternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT steffenthiel patternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT troelskraruphansen patternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes AT perhenrikgroop patternrecognitionmoleculehficolininrelationtodiabetickidneydiseasemortalityandcardiovasculareventsintype1diabetes |
_version_ |
1721492061411082240 |