Host Response during Yersinia pestis Infection of Human Bronchial Epithelial Cells Involves Negative Regulation of Autophagy and Suggests a Modulation of Survival-Related and Cellular Growth Pathways

Host Response during Yersinia pestis Infection of Human Bronchial Epithelial Cells Involves Negative Regulation of Autophagy and Suggests a Modulation of Survival-Related and Cellular Growth Pathways

Yersinia pestis (Yp) causes the re-emerging disease plague, and is classified by the CDC and NIAID as a highest priority (Category A) pathogen. Currently, there is no approved human vaccine available and advances in early diagnostics and effective therapeutics are urgently needed. A deep understandi...

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Bibliographic Details
Main Authors: Farhang eAlem, Kuan eYao, Douglas eLane, Valarie eCalvert, Emanuel F Petricoin, Liana eKramer, Martha L Hale, Sina eBavari, Rekha ePanchal, Ramin M Hakami
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Microbiology
Subjects:
Proteomics
Yersinia pestis
cell growth
host response
Signaling Pathways
apoptosis and autophagy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00050/full

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