The neurocognitive profile of post‐traumatic stress disorder (PTSD), major depressive disorder (MDD), and PTSD with comorbid MDD
Abstract Objective Neurocognitive dysfunction has been associated with post‐traumatic stress disorder (PTSD) and major depressive disorder (MDD). However, although PTSD is often comorbid with MDD, there is little neurocognitive work to date on individuals who suffer from both PTSD and MDD. Here, we...
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doaj-57ded6574fde461f8b0e714919a19a6e2021-04-10T05:08:01ZengWileyBrain and Behavior2162-32792021-04-01114n/an/a10.1002/brb3.1950The neurocognitive profile of post‐traumatic stress disorder (PTSD), major depressive disorder (MDD), and PTSD with comorbid MDDSheri‐Michelle Koopowitz0Karen Thea Maré1Heather J. Zar2Dan J. Stein3Jonathan C. Ipser4Department of Psychiatry & Neuroscience Institute Faculty of Health Sciences University of Cape Town Cape Town South AfricaDepartment of Psychiatry & Neuroscience Institute Faculty of Health Sciences University of Cape Town Cape Town South AfricaUnit on Child & Adolescent Health South African Medical Research Council (SAMRC) Cape Town South AfricaDepartment of Psychiatry & Neuroscience Institute Faculty of Health Sciences University of Cape Town Cape Town South AfricaDepartment of Psychiatry & Neuroscience Institute Faculty of Health Sciences University of Cape Town Cape Town South AfricaAbstract Objective Neurocognitive dysfunction has been associated with post‐traumatic stress disorder (PTSD) and major depressive disorder (MDD). However, although PTSD is often comorbid with MDD, there is little neurocognitive work to date on individuals who suffer from both PTSD and MDD. Here, we compared neurocognitive domains in individuals with PTSD, MDD, and comorbid PTSD and MDD with those of healthy controls. Methods Participants comprised of mothers enrolled in the Drakenstein Child Health Study, a study exploring child health determinants in the Drakenstein district, Western Cape. N = 175 mothers (between 18 and 50 years) were recruited and divided into 4 groups: PTSD, MDD, PTSD with MDD, and healthy controls. Participants were assessed using the computerized NIH Toolbox, and paper and pencil neurocognitive tests. Domains assessed included executive function, memory, attention, learning, and processing speed. Results Distinct patterns of neurocognitive dysfunction were observed in this sample. PTSD was associated with more intrusion errors and MDD was associated with delayed recall impairment, relative to healthy controls. PTSD with comorbid MDD was associated with processing speed impairments, relative to healthy controls, and monodiagnostic groups. No group differences were observed on measures of attention and executive function. Conclusion Distinct patterns of neurocognitive dysfunction were associated with diagnoses of MDD and PTSD. Greater anticipated dysfunction and impairment in comorbid PTSD and MDD was not observed, however. Further work is needed to replicate and extend these findings.https://doi.org/10.1002/brb3.1950cognitioncognitive dysfunctioncomorbiditydepressionPTSD |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sheri‐Michelle Koopowitz Karen Thea Maré Heather J. Zar Dan J. Stein Jonathan C. Ipser |
spellingShingle |
Sheri‐Michelle Koopowitz Karen Thea Maré Heather J. Zar Dan J. Stein Jonathan C. Ipser The neurocognitive profile of post‐traumatic stress disorder (PTSD), major depressive disorder (MDD), and PTSD with comorbid MDD Brain and Behavior cognition cognitive dysfunction comorbidity depression PTSD |
author_facet |
Sheri‐Michelle Koopowitz Karen Thea Maré Heather J. Zar Dan J. Stein Jonathan C. Ipser |
author_sort |
Sheri‐Michelle Koopowitz |
title |
The neurocognitive profile of post‐traumatic stress disorder (PTSD), major depressive disorder (MDD), and PTSD with comorbid MDD |
title_short |
The neurocognitive profile of post‐traumatic stress disorder (PTSD), major depressive disorder (MDD), and PTSD with comorbid MDD |
title_full |
The neurocognitive profile of post‐traumatic stress disorder (PTSD), major depressive disorder (MDD), and PTSD with comorbid MDD |
title_fullStr |
The neurocognitive profile of post‐traumatic stress disorder (PTSD), major depressive disorder (MDD), and PTSD with comorbid MDD |
title_full_unstemmed |
The neurocognitive profile of post‐traumatic stress disorder (PTSD), major depressive disorder (MDD), and PTSD with comorbid MDD |
title_sort |
neurocognitive profile of post‐traumatic stress disorder (ptsd), major depressive disorder (mdd), and ptsd with comorbid mdd |
publisher |
Wiley |
series |
Brain and Behavior |
issn |
2162-3279 |
publishDate |
2021-04-01 |
description |
Abstract Objective Neurocognitive dysfunction has been associated with post‐traumatic stress disorder (PTSD) and major depressive disorder (MDD). However, although PTSD is often comorbid with MDD, there is little neurocognitive work to date on individuals who suffer from both PTSD and MDD. Here, we compared neurocognitive domains in individuals with PTSD, MDD, and comorbid PTSD and MDD with those of healthy controls. Methods Participants comprised of mothers enrolled in the Drakenstein Child Health Study, a study exploring child health determinants in the Drakenstein district, Western Cape. N = 175 mothers (between 18 and 50 years) were recruited and divided into 4 groups: PTSD, MDD, PTSD with MDD, and healthy controls. Participants were assessed using the computerized NIH Toolbox, and paper and pencil neurocognitive tests. Domains assessed included executive function, memory, attention, learning, and processing speed. Results Distinct patterns of neurocognitive dysfunction were observed in this sample. PTSD was associated with more intrusion errors and MDD was associated with delayed recall impairment, relative to healthy controls. PTSD with comorbid MDD was associated with processing speed impairments, relative to healthy controls, and monodiagnostic groups. No group differences were observed on measures of attention and executive function. Conclusion Distinct patterns of neurocognitive dysfunction were associated with diagnoses of MDD and PTSD. Greater anticipated dysfunction and impairment in comorbid PTSD and MDD was not observed, however. Further work is needed to replicate and extend these findings. |
topic |
cognition cognitive dysfunction comorbidity depression PTSD |
url |
https://doi.org/10.1002/brb3.1950 |
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