Vitamin D receptor gene polymorphism in rheumatoid arthritis and its association with atherosclerosis

• Main Authors: Amal M El-Barbary, Manal S Hussein, Elsayed M Rageh, Salwa A Essa, Hossam A Zaytoun
• Format: Article
• Language: English
• Published: SpringerOpen 2015-01-01
• Series: Egyptian Rheumatology and Rehabilitation
• Subjects: atherosclerosis, vitamin D, rheumatoid arthritis
• Online Access: http://www.err.eg.net/article.asp?issn=1110-161X;year=2015;volume=42;issue=3;spage=145;epage=152;aulast=El-Barbary

Aim of the work Determine vitamin D receptor gene BsmI, FokI polymorphism and 25-hydroxyvitamin D in early Egyptian rheumatoid patients and its association to subclinical atherosclerosis. Patients and methods This study included forty early rheumatoid arthritis patients and forty healthy controls. Disease activity score 28 (DAS-28), Modified Health Assessment Questionnaire (MHAQ), Carotid intima-media thickness (cIMT) were assessed using B-mode ultrasound, Erythrocyte sedimentation rate (ESR), C reactive protein (CRP), Lipid profile, anti cyclic citrullinated PolyPeptid (anti-CCP), serum interleukin-6, Total serum vitamin D and genotype determination of BsmI, FokI polymorphism and allel frequency were measured. Results Vitamin D deficiency was observed in 25% of patients. There was no significant difference between RA patients and controls regarding the distribution of BsmI genotype frequencies and allele. However, a significant difference between rheumatoid arthritis patients and controls regarding the distribution of FokI genotype and allele frequencies was found. In addition, FokI polymorphism and the F allele was significantly associated with RA. anti-CCP, interleukin-6 levels, (cIMT) and vitamin D deficiency were significantly higher in the presence of bb homozygote of BsmI genotypes and FF homozygote of FokI genotypes. A significant negative correlation between 25 hydroxy vitamin D levels with (DAS-28), ESR, (CRP), and IL-6 (P < 0.001). However, there was positive correlation between 25 hydroxyvitamin D levels and HDL-C (P < 0.001).