Genetics of Severe Cutaneous Adverse Reactions
Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS) are T cells-mediated life-threatening immune reactions, most commonly induced by drug. The last decade has seen signifi...
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doaj-57eb53f300ce4bd48036a30fba63e05c2021-07-15T11:01:25ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-07-01810.3389/fmed.2021.652091652091Genetics of Severe Cutaneous Adverse ReactionsShang-Chen Yang0Chun-Bing Chen1Chun-Bing Chen2Chun-Bing Chen3Chun-Bing Chen4Chun-Bing Chen5Chun-Bing Chen6Chun-Bing Chen7Mao-Ying Lin8Zhi-Yang Zhang9Xiao-Yan Jia10Ming Huang11Ya-Fen Zou12Wen-Hung Chung13Wen-Hung Chung14Wen-Hung Chung15Wen-Hung Chung16Wen-Hung Chung17Wen-Hung Chung18Wen-Hung Chung19Wen-Hung Chung20Wen-Hung Chung21Department of Dermatology, Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, ChinaDepartment of Dermatology, Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, ChinaDepartment of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taoyuan, TaiwanCancer Vaccine and Immune Cell Therapy Core Laboratory, Department of Medical Research, Chang Gung Memorial Hospital, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanWhole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, TaiwanGraduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, TaiwanImmune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, TaiwanDepartment of Dermatology, Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, ChinaDepartment of Dermatology, Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, ChinaDepartment of Neurology, Xiamen Chang Gung Hospital, Xiamen, ChinaDepartment of Neurology, Xiamen Chang Gung Hospital, Xiamen, ChinaDepartment of Neurology, Xiamen Chang Gung Hospital, Xiamen, ChinaDepartment of Dermatology, Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, ChinaDepartment of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taoyuan, TaiwanCancer Vaccine and Immune Cell Therapy Core Laboratory, Department of Medical Research, Chang Gung Memorial Hospital, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanWhole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, TaiwanImmune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, TaiwanDepartment of Dermatology, Beijing Tsinghua Chang Gung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China0Department of Dermatology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China1Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, TaiwanSevere cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS) are T cells-mediated life-threatening immune reactions, most commonly induced by drug. The last decade has seen significant progress in SCARs research. Recent studies have unveiled the pathogenesis of SCARs involved in susceptible genes, including human leukocyte antigens (HLA) and drugs-T cell receptor (TCR) interaction that may trigger T cell activation with downstream immune signaling of cytokines/chemokines and specific cytotoxic proteins releases. Advances in identification of multiple genetic alleles associated with specific drugs related SCARS in different populations is an important breakthrough in recent years for prevention of SCARs. This article summarized the findings on genetic factors related to SJS/TEN, especially for HLA.https://www.frontiersin.org/articles/10.3389/fmed.2021.652091/fullgenetic screenStevens–Johnson syndrometoxic epidermal necrolysispharmacogenomicsevere cutaneous adverse drug reactions |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shang-Chen Yang Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Mao-Ying Lin Zhi-Yang Zhang Xiao-Yan Jia Ming Huang Ya-Fen Zou Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung |
spellingShingle |
Shang-Chen Yang Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Mao-Ying Lin Zhi-Yang Zhang Xiao-Yan Jia Ming Huang Ya-Fen Zou Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Genetics of Severe Cutaneous Adverse Reactions Frontiers in Medicine genetic screen Stevens–Johnson syndrome toxic epidermal necrolysis pharmacogenomic severe cutaneous adverse drug reactions |
author_facet |
Shang-Chen Yang Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Mao-Ying Lin Zhi-Yang Zhang Xiao-Yan Jia Ming Huang Ya-Fen Zou Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung |
author_sort |
Shang-Chen Yang |
title |
Genetics of Severe Cutaneous Adverse Reactions |
title_short |
Genetics of Severe Cutaneous Adverse Reactions |
title_full |
Genetics of Severe Cutaneous Adverse Reactions |
title_fullStr |
Genetics of Severe Cutaneous Adverse Reactions |
title_full_unstemmed |
Genetics of Severe Cutaneous Adverse Reactions |
title_sort |
genetics of severe cutaneous adverse reactions |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2021-07-01 |
description |
Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS) are T cells-mediated life-threatening immune reactions, most commonly induced by drug. The last decade has seen significant progress in SCARs research. Recent studies have unveiled the pathogenesis of SCARs involved in susceptible genes, including human leukocyte antigens (HLA) and drugs-T cell receptor (TCR) interaction that may trigger T cell activation with downstream immune signaling of cytokines/chemokines and specific cytotoxic proteins releases. Advances in identification of multiple genetic alleles associated with specific drugs related SCARS in different populations is an important breakthrough in recent years for prevention of SCARs. This article summarized the findings on genetic factors related to SJS/TEN, especially for HLA. |
topic |
genetic screen Stevens–Johnson syndrome toxic epidermal necrolysis pharmacogenomic severe cutaneous adverse drug reactions |
url |
https://www.frontiersin.org/articles/10.3389/fmed.2021.652091/full |
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