Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities.
Tissue inhibitor of metalloproteinases-1 (TIMP-1) regulates the extracellular matrix turnover by inhibiting the proteolytic activity of matrix metalloproteinases (MMPs). TIMP-1 also displays MMP-independent activities that influence the behavior of various cell types including neuronal plasticity, b...
Main Authors: | Jessica Thevenard, Laurie Verzeaux, Jerôme Devy, Nicolas Etique, Albin Jeanne, Christophe Schneider, Cathy Hachet, Géraldine Ferracci, Marion David, Laurent Martiny, Emmanuelle Charpentier, Michel Khrestchatisky, Santiago Rivera, Stéphane Dedieu, Hervé Emonard |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4116228?pdf=render |
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