Nodular lymphocyte predominant Hodgkin lymphoma and diphenylhydantoin: Report of a case and review of the literature
A variety of lymphoma types have been reported in patients being treated with anticonvulsant therapy. Non-Hodgkin lymphomas have been reported twice as frequently as Hodgkin lymphomas. Association of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) with dilantin therapy is extremely uncommon....
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Wolters Kluwer Medknow Publications
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doaj-57ed040c0e4b4ef48d317bd8ce9523ac2020-11-24T22:30:07ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292013-01-0156444044210.4103/0377-4929.125364Nodular lymphocyte predominant Hodgkin lymphoma and diphenylhydantoin: Report of a case and review of the literatureShobhna SharmaHari MenonManju SengarSumeet GujralA variety of lymphoma types have been reported in patients being treated with anticonvulsant therapy. Non-Hodgkin lymphomas have been reported twice as frequently as Hodgkin lymphomas. Association of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) with dilantin therapy is extremely uncommon. We report a case of Hodgkin lymphoma in a 25-year-old male patient who had been treated with diphenylhydantoin sodium for generalized tonic clonic seizures for 15 years. Patient presented with left cervical and axillary lymphadenopathy persisting for more than 2 years after cessation of treatment with diphenylhydantoin. Computerized tomography scan of thorax, abdomen and pelvis revealed no significant lymphadenopathy or any organomegaly. Diagnosis of NLPHL was made on excision biopsy of the cervical lymph node. Although the association between diphenylhydantoin therapy and the development of immunosuppression and lymphoma is well-documented, the role of the drug in the etiology of these disorders is still controversial.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2013;volume=56;issue=4;spage=440;epage=442;aulast=SharmaDiphenylhydantoinnodular lymphocyte predominant Hodgkin lymphomalymphadenopathygeneralized tonic clonic seizures |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shobhna Sharma Hari Menon Manju Sengar Sumeet Gujral |
spellingShingle |
Shobhna Sharma Hari Menon Manju Sengar Sumeet Gujral Nodular lymphocyte predominant Hodgkin lymphoma and diphenylhydantoin: Report of a case and review of the literature Indian Journal of Pathology and Microbiology Diphenylhydantoin nodular lymphocyte predominant Hodgkin lymphoma lymphadenopathy generalized tonic clonic seizures |
author_facet |
Shobhna Sharma Hari Menon Manju Sengar Sumeet Gujral |
author_sort |
Shobhna Sharma |
title |
Nodular lymphocyte predominant Hodgkin lymphoma and diphenylhydantoin: Report of a case and review of the literature |
title_short |
Nodular lymphocyte predominant Hodgkin lymphoma and diphenylhydantoin: Report of a case and review of the literature |
title_full |
Nodular lymphocyte predominant Hodgkin lymphoma and diphenylhydantoin: Report of a case and review of the literature |
title_fullStr |
Nodular lymphocyte predominant Hodgkin lymphoma and diphenylhydantoin: Report of a case and review of the literature |
title_full_unstemmed |
Nodular lymphocyte predominant Hodgkin lymphoma and diphenylhydantoin: Report of a case and review of the literature |
title_sort |
nodular lymphocyte predominant hodgkin lymphoma and diphenylhydantoin: report of a case and review of the literature |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Pathology and Microbiology |
issn |
0377-4929 |
publishDate |
2013-01-01 |
description |
A variety of lymphoma types have been reported in patients being treated with anticonvulsant therapy. Non-Hodgkin lymphomas have been reported twice as frequently as Hodgkin lymphomas. Association of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) with dilantin therapy is extremely uncommon. We report a case of Hodgkin lymphoma in a 25-year-old male patient who had been treated with diphenylhydantoin sodium for generalized tonic clonic seizures for 15 years. Patient presented with left cervical and axillary lymphadenopathy persisting for more than 2 years after cessation of treatment with diphenylhydantoin. Computerized tomography scan of thorax, abdomen and pelvis revealed no significant lymphadenopathy or any organomegaly. Diagnosis of NLPHL was made on excision biopsy of the cervical lymph node. Although the association between diphenylhydantoin therapy and the development of immunosuppression and lymphoma is well-documented, the role of the drug in the etiology of these disorders is still controversial. |
topic |
Diphenylhydantoin nodular lymphocyte predominant Hodgkin lymphoma lymphadenopathy generalized tonic clonic seizures |
url |
http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2013;volume=56;issue=4;spage=440;epage=442;aulast=Sharma |
work_keys_str_mv |
AT shobhnasharma nodularlymphocytepredominanthodgkinlymphomaanddiphenylhydantoinreportofacaseandreviewoftheliterature AT harimenon nodularlymphocytepredominanthodgkinlymphomaanddiphenylhydantoinreportofacaseandreviewoftheliterature AT manjusengar nodularlymphocytepredominanthodgkinlymphomaanddiphenylhydantoinreportofacaseandreviewoftheliterature AT sumeetgujral nodularlymphocytepredominanthodgkinlymphomaanddiphenylhydantoinreportofacaseandreviewoftheliterature |
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1725741835429609472 |