Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells.

Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells.

<h4>Background</h4>Using human brain microvascular endothelial cells (HBMECs) as an in vitro model for how African trypanosomes cross the human blood-brain barrier (BBB) we recently reported that the parasites cross the BBB by generating calcium activation signals in HBMECs through the a...

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Main Authors: Dennis J Grab, Jose C Garcia-Garcia, Olga V Nikolskaia, Yuri V Kim, Amanda Brown, Carlos A Pardo, Yongqing Zhang, Kevin G Becker, Brenda A Wilson, Ana Paula C de A Lima, Julio Scharfstein, J Stephen Dumler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19621073/pdf/?tool=EBI

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