DeltaF508 CFTR Hetero- and Homozygous Paediatric Patients with Cystic Fibrosis Do Not Differ with Regard to Nutritional Status
The purpose of this study was to compare the nutritional status between deltaF508 CFTR hetero- and homozygous paediatric patients with cystic fibrosis. We assessed the percentage profiles of fatty acids measured in erythrocyte membranes and the serum levels of vitamins A, D3, E and K1 in the studied...
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doaj-57f21a1d3fa24c55963405ece06854da2021-04-21T23:07:45ZengMDPI AGNutrients2072-66432021-04-01131402140210.3390/nu13051402DeltaF508 CFTR Hetero- and Homozygous Paediatric Patients with Cystic Fibrosis Do Not Differ with Regard to Nutritional StatusAleksandra Mędza0Katarzyna Kaźmierska1Bartosz Wielgomas2Lucyna Konieczna3Ilona Olędzka4Agnieszka Szlagatys-Sidorkiewicz5Katarzyna Sznurkowska6Department of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Copernicus Hospital, Nowe Ogrody 1-6, 80-803 Gdańsk, PolandMedical Clinic “Na Wzgórzu”, Jaworzniaków 37, 80-180 Gdańsk, PolandDepartment of Toxicology, Faculty of Pharmacy, Medical University of Gdańsk, Al. J. Gen. Hallera 107, 80-416 Gdańsk, PolandDepartment of Pharmaceutical Chemistry, Medical University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdansk, PolandDepartment of Pharmaceutical Chemistry, Medical University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdansk, PolandDepartment of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdańsk, Nowe Ogrody 1-6, 80-803 Gdańsk, PolandDepartment of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdańsk, Nowe Ogrody 1-6, 80-803 Gdańsk, PolandThe purpose of this study was to compare the nutritional status between deltaF508 CFTR hetero- and homozygous paediatric patients with cystic fibrosis. We assessed the percentage profiles of fatty acids measured in erythrocyte membranes and the serum levels of vitamins A, D3, E and K1 in the studied groups. We also measured the weights and heights and calculated the body mass indexes (BMIs). The studied groups consisted of 34 heterozygous and 30 homozygous patients. No statistically significant differences were found in the serum vitamins or erythrocyte membrane fatty acid profiles between the hetero- and homozygous patient groups, except for heptadecanoic acid (<i>p</i> = 0.038). The mean percentiles of height, weight and BMI did not differ significantly between the two groups. The homozygous and heterozygous paediatric patients with cystic fibrosis were similar in terms of their nutritional statuses.https://www.mdpi.com/2072-6643/13/5/1402cystic fibrosisnutritional statusfatty acidsvitaminsbody composition |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aleksandra Mędza Katarzyna Kaźmierska Bartosz Wielgomas Lucyna Konieczna Ilona Olędzka Agnieszka Szlagatys-Sidorkiewicz Katarzyna Sznurkowska |
spellingShingle |
Aleksandra Mędza Katarzyna Kaźmierska Bartosz Wielgomas Lucyna Konieczna Ilona Olędzka Agnieszka Szlagatys-Sidorkiewicz Katarzyna Sznurkowska DeltaF508 CFTR Hetero- and Homozygous Paediatric Patients with Cystic Fibrosis Do Not Differ with Regard to Nutritional Status Nutrients cystic fibrosis nutritional status fatty acids vitamins body composition |
author_facet |
Aleksandra Mędza Katarzyna Kaźmierska Bartosz Wielgomas Lucyna Konieczna Ilona Olędzka Agnieszka Szlagatys-Sidorkiewicz Katarzyna Sznurkowska |
author_sort |
Aleksandra Mędza |
title |
DeltaF508 CFTR Hetero- and Homozygous Paediatric Patients with Cystic Fibrosis Do Not Differ with Regard to Nutritional Status |
title_short |
DeltaF508 CFTR Hetero- and Homozygous Paediatric Patients with Cystic Fibrosis Do Not Differ with Regard to Nutritional Status |
title_full |
DeltaF508 CFTR Hetero- and Homozygous Paediatric Patients with Cystic Fibrosis Do Not Differ with Regard to Nutritional Status |
title_fullStr |
DeltaF508 CFTR Hetero- and Homozygous Paediatric Patients with Cystic Fibrosis Do Not Differ with Regard to Nutritional Status |
title_full_unstemmed |
DeltaF508 CFTR Hetero- and Homozygous Paediatric Patients with Cystic Fibrosis Do Not Differ with Regard to Nutritional Status |
title_sort |
deltaf508 cftr hetero- and homozygous paediatric patients with cystic fibrosis do not differ with regard to nutritional status |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-04-01 |
description |
The purpose of this study was to compare the nutritional status between deltaF508 CFTR hetero- and homozygous paediatric patients with cystic fibrosis. We assessed the percentage profiles of fatty acids measured in erythrocyte membranes and the serum levels of vitamins A, D3, E and K1 in the studied groups. We also measured the weights and heights and calculated the body mass indexes (BMIs). The studied groups consisted of 34 heterozygous and 30 homozygous patients. No statistically significant differences were found in the serum vitamins or erythrocyte membrane fatty acid profiles between the hetero- and homozygous patient groups, except for heptadecanoic acid (<i>p</i> = 0.038). The mean percentiles of height, weight and BMI did not differ significantly between the two groups. The homozygous and heterozygous paediatric patients with cystic fibrosis were similar in terms of their nutritional statuses. |
topic |
cystic fibrosis nutritional status fatty acids vitamins body composition |
url |
https://www.mdpi.com/2072-6643/13/5/1402 |
work_keys_str_mv |
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