Administration of Gemcitabine for Metastatic Adenocarcinoma during Pregnancy: A Case Report and Review of the Literature
Abstract We present the case of a 38-year-old woman diagnosed with metastatic adenocarcinoma of the biliary tract in the 18th week of pregnancy. Chemotherapy based on cisplatin and gemcitabine was administered, reaching disease stabilization until late-preterm delivery at 35 + 0 weeks of gestation....
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2014-02-01
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doaj-57fffbb13c0e4188bd8e7a6823a926a72020-11-25T03:13:26ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052014-02-0140101702210.1055/s-0034-1368091Administration of Gemcitabine for Metastatic Adenocarcinoma during Pregnancy: A Case Report and Review of the LiteratureM. Wiesweg0S. Aydin1A. Koeninger2A. Stein3U. Schara4C. van Roye5J. Hense6A. Welt7M. Schuler8Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, GermanyDipartimento di Ematologia ed Oncologia, Azienda ospedaliera Città della Salute e della Scienza di Torino, Torino, ItalyDepartment of Gynecology and Obstetrics, University Hospital Essen, University Duisburg-Essen, Essen, GermanyDepartment of Neonatology, Clinic for Pediatrics I, University Hospital Essen, University Duisburg-Essen, Essen, GermanyDepartment of Neuropediatrics, Developmental Neurology and Social Pediatrics, Clinic for Pediatrics I, University Hospital Essen, University Duisburg-Essen, Essen, GermanyHematology/Oncology Group Practice, Koblenz, GermanyDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, GermanyDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, GermanyDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, GermanyAbstract We present the case of a 38-year-old woman diagnosed with metastatic adenocarcinoma of the biliary tract in the 18th week of pregnancy. Chemotherapy based on cisplatin and gemcitabine was administered, reaching disease stabilization until late-preterm delivery at 35 + 0 weeks of gestation. The infant was healthy and showed no malformations. Her head circumference was small, yet no neurological and behavioral defects have been detected. Development was normal during 14 months of follow-up. We discuss the implications of metastatic cancer in pregnancy with focus on therapeutic options for metastatic adenocarcinoma of the biliary tract. In this context, available data for the active regimens in biliary tract cancers—platinum compounds and gemcitabine—are discussed. This report is the fourth in the literature detailing the application of gemcitabine during pregnancy and the first presenting longer term follow-up, complementing available evidence that gemcitabine-based regimens are feasible in this situation.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1368091gemcitabinepregnancyadenocarcinomacholangiocarcinomachemotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. Wiesweg S. Aydin A. Koeninger A. Stein U. Schara C. van Roye J. Hense A. Welt M. Schuler |
spellingShingle |
M. Wiesweg S. Aydin A. Koeninger A. Stein U. Schara C. van Roye J. Hense A. Welt M. Schuler Administration of Gemcitabine for Metastatic Adenocarcinoma during Pregnancy: A Case Report and Review of the Literature American Journal of Perinatology Reports gemcitabine pregnancy adenocarcinoma cholangiocarcinoma chemotherapy |
author_facet |
M. Wiesweg S. Aydin A. Koeninger A. Stein U. Schara C. van Roye J. Hense A. Welt M. Schuler |
author_sort |
M. Wiesweg |
title |
Administration of Gemcitabine for Metastatic Adenocarcinoma during Pregnancy: A Case Report and Review of the Literature |
title_short |
Administration of Gemcitabine for Metastatic Adenocarcinoma during Pregnancy: A Case Report and Review of the Literature |
title_full |
Administration of Gemcitabine for Metastatic Adenocarcinoma during Pregnancy: A Case Report and Review of the Literature |
title_fullStr |
Administration of Gemcitabine for Metastatic Adenocarcinoma during Pregnancy: A Case Report and Review of the Literature |
title_full_unstemmed |
Administration of Gemcitabine for Metastatic Adenocarcinoma during Pregnancy: A Case Report and Review of the Literature |
title_sort |
administration of gemcitabine for metastatic adenocarcinoma during pregnancy: a case report and review of the literature |
publisher |
Thieme Medical Publishers, Inc. |
series |
American Journal of Perinatology Reports |
issn |
2157-6998 2157-7005 |
publishDate |
2014-02-01 |
description |
Abstract
We present the case of a 38-year-old woman diagnosed with metastatic adenocarcinoma of the biliary tract in the 18th week of pregnancy. Chemotherapy based on cisplatin and gemcitabine was administered, reaching disease stabilization until late-preterm delivery at 35 + 0 weeks of gestation. The infant was healthy and showed no malformations. Her head circumference was small, yet no neurological and behavioral defects have been detected. Development was normal during 14 months of follow-up. We discuss the implications of metastatic cancer in pregnancy with focus on therapeutic options for metastatic adenocarcinoma of the biliary tract. In this context, available data for the active regimens in biliary tract cancers—platinum compounds and gemcitabine—are discussed. This report is the fourth in the literature detailing the application of gemcitabine during pregnancy and the first presenting longer term follow-up, complementing available evidence that gemcitabine-based regimens are feasible in this situation. |
topic |
gemcitabine pregnancy adenocarcinoma cholangiocarcinoma chemotherapy |
url |
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1368091 |
work_keys_str_mv |
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1724646760163311616 |