Dissolution Profile of Nimesulide from Pharmaceutical Preparations for Oral Use
Nimesulide belongs to the group of semi-selective COX-2 inhibitors, widely used in solid oral formulations. In the present work the influence of surfactants among other drug excipients, as well as particle size of the active substance and the effects of medium pH on the dissolution rate of nimesulid...
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Slovenian Chemical Society
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doaj-580fa468ea7748e292706907bce394502020-11-25T01:28:54ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552016-02-0163119319910.17344/acsi.2015.2168331Dissolution Profile of Nimesulide from Pharmaceutical Preparations for Oral UseBiljana Tubić0Alija UzunovićSaša PilipovićŽarko GagićAgency for medicines and medical devices of Bosnia and Herzegovina and Faculty of medicine - study program PharmaciaNimesulide belongs to the group of semi-selective COX-2 inhibitors, widely used in solid oral formulations. In the present work the influence of surfactants among other drug excipients, as well as particle size of the active substance and the effects of medium pH on the dissolution rate of nimesulide from solid pharmaceutical forms. For that purpose, four different preparations containing 100 mg nimesulide per tablet and available in the market of Bosnia and Herzegovina (labeled here as A, B, C and D) were studied. The test for the assessment of dissolution profiles of the formulations was performed in surfactant-free dissolution medium pH 7.5. The dissolution profiles were compared by calculating difference (f1), and similarity (f2) factors. The increasing dissolution medium pH value from 7.5 to 7.75 resulted in a significant increase of nimesulide dissolution rate from the examined formulations. Also, the results showed that particle size affects to a great extent the dissolution rate and the best results were achieved with micronized nimesulide. The presence of the surfactants among the other excipients expressed a negligible effect on the dissolution profile.https://journals.matheo.si/index.php/ACSi/article/view/2168nimesulidedissolution ratebioavailability |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Biljana Tubić Alija Uzunović Saša Pilipović Žarko Gagić |
spellingShingle |
Biljana Tubić Alija Uzunović Saša Pilipović Žarko Gagić Dissolution Profile of Nimesulide from Pharmaceutical Preparations for Oral Use Acta Chimica Slovenica nimesulide dissolution rate bioavailability |
author_facet |
Biljana Tubić Alija Uzunović Saša Pilipović Žarko Gagić |
author_sort |
Biljana Tubić |
title |
Dissolution Profile of Nimesulide from Pharmaceutical Preparations for Oral Use |
title_short |
Dissolution Profile of Nimesulide from Pharmaceutical Preparations for Oral Use |
title_full |
Dissolution Profile of Nimesulide from Pharmaceutical Preparations for Oral Use |
title_fullStr |
Dissolution Profile of Nimesulide from Pharmaceutical Preparations for Oral Use |
title_full_unstemmed |
Dissolution Profile of Nimesulide from Pharmaceutical Preparations for Oral Use |
title_sort |
dissolution profile of nimesulide from pharmaceutical preparations for oral use |
publisher |
Slovenian Chemical Society |
series |
Acta Chimica Slovenica |
issn |
1318-0207 1580-3155 |
publishDate |
2016-02-01 |
description |
Nimesulide belongs to the group of semi-selective COX-2 inhibitors, widely used in solid oral formulations. In the present work the influence of surfactants among other drug excipients, as well as particle size of the active substance and the effects of medium pH on the dissolution rate of nimesulide from solid pharmaceutical forms. For that purpose, four different preparations containing 100 mg nimesulide per tablet and available in the market of Bosnia and Herzegovina (labeled here as A, B, C and D) were studied. The test for the assessment of dissolution profiles of the formulations was performed in surfactant-free dissolution medium pH 7.5. The dissolution profiles were compared by calculating difference (f1), and similarity (f2) factors. The increasing dissolution medium pH value from 7.5 to 7.75 resulted in a significant increase of nimesulide dissolution rate from the examined formulations. Also, the results showed that particle size affects to a great extent the dissolution rate and the best results were achieved with micronized nimesulide. The presence of the surfactants among the other excipients expressed a negligible effect on the dissolution profile. |
topic |
nimesulide dissolution rate bioavailability |
url |
https://journals.matheo.si/index.php/ACSi/article/view/2168 |
work_keys_str_mv |
AT biljanatubic dissolutionprofileofnimesulidefrompharmaceuticalpreparationsfororaluse AT alijauzunovic dissolutionprofileofnimesulidefrompharmaceuticalpreparationsfororaluse AT sasapilipovic dissolutionprofileofnimesulidefrompharmaceuticalpreparationsfororaluse AT zarkogagic dissolutionprofileofnimesulidefrompharmaceuticalpreparationsfororaluse |
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