Clonal Groupings in Serogroup X Neisseria meningitidis

• Main Authors: Sébastien Gagneux, Thierry Wirth, Abraham Hodgson, Ingrid Ehrhard, Giovanna Morelli, Paula Kriz, Blaise Genton, Tom Smith, Fred Binka, Gerd Pluschke, Mark Achtman
• Format: Article
• Language: English
• Published: Centers for Disease Control and Prevention 2002-05-01
• Series: Emerging Infectious Diseases
• Subjects: Africa; Burkina Faso; Chad; genotyping; Ghana; Mali
• Online Access: https://wwwnc.cdc.gov/eid/article/8/5/01-0227_article
• ISSN: 1080-6040; 1080-6059

The genetic diversity of 134 serogroup X Neisseria meningitis isolates from Africa, Europe, and North America was analyzed by multilocus sequence typing and pulsed-field gel electrophoresis. Although most European and American isolates were highly diverse, one clonal grouping was identified in sporadic disease and carrier strains isolated over the last 2 decades in the United Kingdom, the Netherlands, Germany, and the United States. In contrast to the diversity in the European and American isolates, most carrier and disease isolates recovered during the last 30 years in countries in the African meningitis belt belonged to a second clonal grouping. During the last decade, these bacteria have caused meningitis outbreaks in Niger and Ghana. These results support the development of a comprehensive conjugate vaccine that would include serogroup X polysaccharide.