LIG4 mediates Wnt signalling-induced radioresistance

The Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a direct target of β-catenin and it specifically medi...

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Main Authors:	Sohee Jun, Youn-Sang Jung, Han Na Suh, Wenqi Wang, Moon Jong Kim, Young Sun Oh, Esther M. Lien, Xi Shen, Yoshihisa Matsumoto, Pierre D. McCrea, Lei Li, Junjie Chen, Jae-Il Park
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms10994

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spelling	doaj-581765a279824025a9bb4b79da323deb2021-05-11T11:20:40ZengNature Publishing GroupNature Communications2041-17232016-03-017111310.1038/ncomms10994LIG4 mediates Wnt signalling-induced radioresistanceSohee Jun0Youn-Sang Jung1Han Na Suh2Wenqi Wang3Moon Jong Kim4Young Sun Oh5Esther M. Lien6Xi Shen7Yoshihisa Matsumoto8Pierre D. McCrea9Lei Li10Junjie Chen11Jae-Il Park12Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterResearch Laboratory for Nuclear Reactors, Tokyo Institute of TechnologyDepartment of Molecular Genetics, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterThe Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a direct target of β-catenin and it specifically mediates non-homologous end joining repair in colorectal cancer cells.https://doi.org/10.1038/ncomms10994
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sohee Jun Youn-Sang Jung Han Na Suh Wenqi Wang Moon Jong Kim Young Sun Oh Esther M. Lien Xi Shen Yoshihisa Matsumoto Pierre D. McCrea Lei Li Junjie Chen Jae-Il Park
spellingShingle	Sohee Jun Youn-Sang Jung Han Na Suh Wenqi Wang Moon Jong Kim Young Sun Oh Esther M. Lien Xi Shen Yoshihisa Matsumoto Pierre D. McCrea Lei Li Junjie Chen Jae-Il Park LIG4 mediates Wnt signalling-induced radioresistance Nature Communications
author_facet	Sohee Jun Youn-Sang Jung Han Na Suh Wenqi Wang Moon Jong Kim Young Sun Oh Esther M. Lien Xi Shen Yoshihisa Matsumoto Pierre D. McCrea Lei Li Junjie Chen Jae-Il Park
author_sort	Sohee Jun
title	LIG4 mediates Wnt signalling-induced radioresistance
title_short	LIG4 mediates Wnt signalling-induced radioresistance
title_full	LIG4 mediates Wnt signalling-induced radioresistance
title_fullStr	LIG4 mediates Wnt signalling-induced radioresistance
title_full_unstemmed	LIG4 mediates Wnt signalling-induced radioresistance
title_sort	lig4 mediates wnt signalling-induced radioresistance
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-03-01
description	The Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a direct target of β-catenin and it specifically mediates non-homologous end joining repair in colorectal cancer cells.
url	https://doi.org/10.1038/ncomms10994
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LIG4 mediates Wnt signalling-induced radioresistance

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