Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study
A cochlear implant (CI) is an auditory prosthesis that enables hearing by providing electrical stimuli through an electrode array. It has been previously established that the electrode position can influence CI performance. Thus, electrode position should be considered in order to achieve better CI...
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doaj-5818a9392eb646ca99471e14fbdb0c142020-11-24T23:13:26ZengHindawi LimitedComputational and Mathematical Methods in Medicine1748-670X1748-67182015-01-01201510.1155/2015/934382934382Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model StudySoojin Kang0Tanmoy Chwodhury1Il Joon Moon2Sung Hwa Hong3Hyejin Yang4Jong Ho Won5Jihwan Woo6School of Electrical Engineering, Biomedical Engineering, University of Ulsan, Ulsan 680-749, Republic of KoreaSchool of Electrical Engineering, Biomedical Engineering, University of Ulsan, Ulsan 680-749, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University, Seoul 330-714, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University, Seoul 330-714, Republic of KoreaSchool of Electrical Engineering, Biomedical Engineering, University of Ulsan, Ulsan 680-749, Republic of KoreaDepartment of Audiology and Speech Pathology, University of Tennessee Health Science Center, Knoxville, TN 37996, USASchool of Electrical Engineering, Biomedical Engineering, University of Ulsan, Ulsan 680-749, Republic of KoreaA cochlear implant (CI) is an auditory prosthesis that enables hearing by providing electrical stimuli through an electrode array. It has been previously established that the electrode position can influence CI performance. Thus, electrode position should be considered in order to achieve better CI results. This paper describes how the electrode position influences the auditory nerve fiber (ANF) response to either a single pulse or low- (250 pulses/s) and high-rate (5,000 pulses/s) pulse-trains using a computational model. The field potential in the cochlea was calculated using a three-dimensional finite-element model, and the ANF response was simulated using a biophysical ANF model. The effects were evaluated in terms of the dynamic range, stochasticity, and spike excitation pattern. The relative spread, threshold, jitter, and initiated node were analyzed for single-pulse response; and the dynamic range, threshold, initiated node, and interspike interval were analyzed for pulse-train stimuli responses. Electrode position was found to significantly affect the spatiotemporal pattern of the ANF response, and this effect was significantly dependent on the stimulus rate. We believe that these modeling results can provide guidance regarding perimodiolar and lateral insertion of CIs in clinical settings and help understand CI performance.http://dx.doi.org/10.1155/2015/934382 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Soojin Kang Tanmoy Chwodhury Il Joon Moon Sung Hwa Hong Hyejin Yang Jong Ho Won Jihwan Woo |
spellingShingle |
Soojin Kang Tanmoy Chwodhury Il Joon Moon Sung Hwa Hong Hyejin Yang Jong Ho Won Jihwan Woo Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study Computational and Mathematical Methods in Medicine |
author_facet |
Soojin Kang Tanmoy Chwodhury Il Joon Moon Sung Hwa Hong Hyejin Yang Jong Ho Won Jihwan Woo |
author_sort |
Soojin Kang |
title |
Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study |
title_short |
Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study |
title_full |
Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study |
title_fullStr |
Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study |
title_full_unstemmed |
Effects of Electrode Position on Spatiotemporal Auditory Nerve Fiber Responses: A 3D Computational Model Study |
title_sort |
effects of electrode position on spatiotemporal auditory nerve fiber responses: a 3d computational model study |
publisher |
Hindawi Limited |
series |
Computational and Mathematical Methods in Medicine |
issn |
1748-670X 1748-6718 |
publishDate |
2015-01-01 |
description |
A cochlear implant (CI) is an auditory prosthesis that enables hearing by providing electrical stimuli through an electrode array. It has been previously established that the electrode position can influence CI performance. Thus, electrode position should be considered in order to achieve better CI results. This paper describes how the electrode position influences the auditory nerve fiber (ANF) response to either a single pulse or low- (250 pulses/s) and high-rate (5,000 pulses/s) pulse-trains using a computational model. The field potential in the cochlea was calculated using a three-dimensional finite-element model, and the ANF response was simulated using a biophysical ANF model. The effects were evaluated in terms of the dynamic range, stochasticity, and spike excitation pattern. The relative spread, threshold, jitter, and initiated node were analyzed for single-pulse response; and the dynamic range, threshold, initiated node, and interspike interval were analyzed for pulse-train stimuli responses. Electrode position was found to significantly affect the spatiotemporal pattern of the ANF response, and this effect was significantly dependent on the stimulus rate. We believe that these modeling results can provide guidance regarding perimodiolar and lateral insertion of CIs in clinical settings and help understand CI performance. |
url |
http://dx.doi.org/10.1155/2015/934382 |
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