Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA

Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA

RNA interference (RNAi) may provide a therapeutic solution to many pulmonary epithelium diseases. However, the main barrier to the clinical use of RNAi remains the lack of efficient delivery vectors. Research has mainly concentrated on the intranasal route of delivery of short interfering RNA (siRNA...

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Bibliographic Details
Main Authors: Jana McCaskill, Richa Singhania, Melinda Burgess, Rachel Allavena, Sherry Wu, Antje Blumenthal, Nigel AJ McMillan
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
endothelial
epithelial
in vivo
lung
siRNA
stealth liposome
Online Access:http://www.sciencedirect.com/science/article/pii/S216225311630155X

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